Reference : Hemolytic activity of new linear surfactin analogs in relation to their physico-chemical...

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology Life sciences : Microbiology
	To cite this reference:	http://hdl.handle.net/2268/37979

Title :	Hemolytic activity of new linear surfactin analogs in relation to their physico-chemical properties
Language :	English
Author, co-author :	Dufour, Samuel [> >]
	Deleu, Magali [Université de Liège - ULg > Chimie et bio-industries > Chimie biologique industrielle >]
	Nott, Katherine [Université de Liège - ULg > Chimie et bio-industries > Chimie biologique industrielle >]
	Wathelet, Bernard [Université de Liège - ULg > Chimie et bio-industries > Chimie biologique industrielle >]
	Thonart, Philippe [Université de Liège - ULg > Département des sciences de la vie > Biochimie et microbiologie industrielles - Bio-industries >]
	Paquot, Michel [Université de Liège - ULg > Chimie et bio-industries > Chimie biologique industrielle >]
Publication date :	2005
Journal title :	Biochimica et Biophysica Acta - General Subjects
Publisher :	Elsevier Science
Volume :	1726
Pages :	87-95
Audience :	International
ISSN :	0304-4165
City :	Amsterdam
Keywords :	[en] Surfactin ; CMC ; Hemolysis ; Surfactin analog
Abstract :	[en] New linear analogs of surfactin have been synthesized. Their physico-chemical parameters were determined. The results indicate that these linear products show surface activities although they are lowered compared to those of cyclic compounds. The hemolytic activities have also been assayed. In contrast with cyclic surfactins, no significant hemolysis occurs for the linear products in the range of concentrations tested. Moreover, a protective effect against Triton X-100 induced hemolysis has been highlighted for linear surfactins. The concentration at which this protective effect happens is correlated directly to the CMC, and inversely to the acyl chain length of the product. In a hypotonic medium, analogs having a long acyl chain tend to increase the hemolysis, meanwhile the product with the shortest chain tends to decrease it.
Permalink :	http://hdl.handle.net/2268/37979

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