Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons.

Seutin, Vincent; Johnson, S. W.; North, R. A.

doi:10.1016/0006-8993(93)90675-D

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Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons.

Seutin, Vincent; Johnson, S. W.; North, R. A.

1993 • In Brain Research, 630 (1-2), p. 341-4

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https://hdl.handle.net/2268/37753

DOI
10.1016/0006-8993(93)90675-D

PubMed
8118703

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Keywords :

Action Potentials/drug effects; Animals; Apamin/pharmacology; Dopamine/analysis; Male; N-Methylaspartate/pharmacology; Neurons/chemistry/drug effects; Potassium Channels/drug effects; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area/drug effects

Abstract :

[en] Intracellular recordings made in vitro from rat midbrain dopamine neurons showed that apamin (100 nM) did not alter the regular spontaneous firing of the neurons, but it increased the occurrence of bursts of action potentials in N-methyl-D-aspartate. Apamin appeared to facilitate burst-firing induced by NMDA because, by blocking an outward calcium-activated potassium current, it increased the depolarizing action of NMDA.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Seutin, Vincent ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie

Johnson, S. W.

North, R. A.

Language :

English

Title :

Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons.

Publication date :

1993

Journal title :

Brain Research

ISSN :

0006-8993

eISSN :

1872-6240

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

630

Issue :

1-2

Pages :

341-4

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 20 May 2010

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Bibliography

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