Reference : Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons.
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons.
Seutin, Vincent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
Johnson, S. W. [> > > >]
North, R. A. [> > > >]
Brain Research
Elsevier Science
Yes (verified by ORBi)
The Netherlands
[en] Action Potentials/drug effects ; Animals ; Apamin/pharmacology ; Dopamine/analysis ; Male ; N-Methylaspartate/pharmacology ; Neurons/chemistry/drug effects ; Potassium Channels/drug effects ; Rats ; Rats, Sprague-Dawley ; Ventral Tegmental Area/drug effects
[en] Intracellular recordings made in vitro from rat midbrain dopamine neurons showed that apamin (100 nM) did not alter the regular spontaneous firing of the neurons, but it increased the occurrence of bursts of action potentials in N-methyl-D-aspartate. Apamin appeared to facilitate burst-firing induced by NMDA because, by blocking an outward calcium-activated potassium current, it increased the depolarizing action of NMDA.

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