Reference : Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons.

	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology
	To cite this reference:	http://hdl.handle.net/2268/37753

Title :	Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons.
Language :	English
Author, co-author :	Seutin, Vincent [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
	Johnson, S. W. [> > > >]
	North, R. A. [> > > >]
Publication date :	1993
Journal title :	Brain Research
Publisher :	Elsevier Science
Volume :	630
Issue/season :	1-2
Pages :	341-4
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0006-8993
City :	Amsterdam
Country :	The Netherlands
Keywords :	[en] Action Potentials/drug effects ; Animals ; Apamin/pharmacology ; Dopamine/analysis ; Male ; N-Methylaspartate/pharmacology ; Neurons/chemistry/drug effects ; Potassium Channels/drug effects ; Rats ; Rats, Sprague-Dawley ; Ventral Tegmental Area/drug effects
Abstract :	[en] Intracellular recordings made in vitro from rat midbrain dopamine neurons showed that apamin (100 nM) did not alter the regular spontaneous firing of the neurons, but it increased the occurrence of bursts of action potentials in N-methyl-D-aspartate. Apamin appeared to facilitate burst-firing induced by NMDA because, by blocking an outward calcium-activated potassium current, it increased the depolarizing action of NMDA.
Permalink :	http://hdl.handle.net/2268/37753

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