Reference : Electrophysiological effects of ethanol on monoaminergic neurons: an in vivo and in vitr...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/37747
Electrophysiological effects of ethanol on monoaminergic neurons: an in vivo and in vitro study.
English
Verbanck, P. [> > > >]
Seutin, Vincent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
Dresse, Albert mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Scuvée-Moreau, Jacqueline mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie - Département des sciences biomédicales et précliniques >]
Massotte, Laurent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Giesbers, Irène [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
Kornreich, C. [> > > >]
1990
Alcoholism, Clinical & Experimental Research
Blackwell Publishing
14
5
728-35
Yes (verified by ORBi)
International
0145-6008
1530-0277
Oxford
United Kingdom
[en] Animals ; Brain/drug effects ; Brain Mapping ; Dose-Response Relationship, Drug ; Ethanol/pharmacology ; Evoked Potentials/drug effects ; Locus Coeruleus/drug effects ; Male ; Neurons/drug effects ; Raphe Nuclei/drug effects ; Rats ; Synaptic Transmission/drug effects ; Tegmentum Mesencephali/drug effects
[en] Monoaminergic neurons have been shown to play a role in both the intoxicating and chronic effects of ethanol. We present here the results of a study about the acute effects of ethanol on serotonergic raphe nucleus, noradrenergic locus coeruleus, and dopaminergic ventral tegmental area. These nuclei were investigated electrophysiologically by recording the spontaneous firing rate of single neurons using glass microelectrodes, both in vivo in chloral hydrate anesthetized rats and in vitro in brain slices. Ethanol was perfused intravenously at a rate ranging from 0.2 mg/kg/min to 0.2 g/kg/min in vivo, and at concentrations between 10(-8) M and 1 M in vitro. We observed that each monoaminergic nucleus had its own pattern of responses to acute ethanol perfusion, and that high and low concentrations have different actions, suggesting a biphasic effect. For example, in slices, ethanol concentrations higher than 10 mM induce an excitation in most raphe and ventral tegmental area neurons, and an inhibition of firing in locus coeruleus neurons. The results were comparable in the in vivo model, but much more heterogenous. We conclude that the effect of ethanol on the monoaminergic neurons is specific of the type of neuron, and that a biphasic effect is commonly found.
http://hdl.handle.net/2268/37747

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