Reference : Yohimbine can induce ethanol tolerance in an in vitro preparation of rat locus coeruleus.
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/37746
Yohimbine can induce ethanol tolerance in an in vitro preparation of rat locus coeruleus.
English
Verbanck, P. [> > > >]
Seutin, Vincent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
Massotte, Laurent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Dresse, Albert mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
1991
Alcoholism, Clinical & Experimental Research
Blackwell Publishing
15
6
1036-9
Yes (verified by ORBi)
International
0145-6008
1530-0277
Oxford
United Kingdom
[en] Animals ; Clonidine/pharmacology ; Culture Techniques ; Drug Tolerance ; Ethanol/pharmacology ; Locus Coeruleus/drug effects ; Male ; Neurons/drug effects ; Norepinephrine/physiology ; Rats ; Rats, Inbred Strains ; Receptors, Adrenergic/drug effects ; Yohimbine/pharmacology
[en] Noradrenergic neurons have been implicated in the development of ethanol dependence and tolerance. Moreover, the development of an hyposensitivity of alpha 2 adrenoceptors has been postulated during long-term exposition to ethanol. In order to test the putative role of alpha 2 receptors in ethanol intoxication, we have studied the interaction between ethanol and yohimbine, an alpha 2 antagonist, on the spontaneous firing rate of rat locus coeruleus (LC) in an in vitro slice model. The spikes from single neurons were recorded by glass microelectrodes. Ethanol at 100 mM, a concentration that parallels the behavioral effects in the human and in the animals, inhibits the firing activity of some LC cells. This inhibition was quickly reversed after stopping the ethanol perfusion and was observed for each further administration. However, if yohimbine (20 microM) was simultaneously perfused, the ethanol-induced inhibition was rapidly antagonized. This effect is reversible after long time washout of yohimbine. This suggests that alpha 2 adrenoceptors could be implicated in the inhibitory effect of ethanol on LC noradrenergic neurons and perhaps in the development of tolerance. However, other hypotheses are discussed, because yohimbine can also antagonize other types of receptors.
http://hdl.handle.net/2268/37746

There is no file associated with this reference.

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.