ORBi: Laureys Steven - Experience-dependent changes in cerebral functional connectivity during human rapid eye movement sleep

Reference : Experience-dependent changes in cerebral functional connectivity during human rapid eye ...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Neurology Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/37678

Title :	Experience-dependent changes in cerebral functional connectivity during human rapid eye movement sleep
Language :	English
Author, co-author :	Laureys, Steven [Université de Liège - ULg > > Centre de recherches du cyclotron]
	Peigneux, Philippe [Université de Liège - ULg > Département des sciences cognitives > Département des sciences cognitives >]
	Phillips, Christophe [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Fuchs, Sonia [> > > >]
	Degueldre, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Aerts, Joël [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Del Fiore, Guy [> > > >]
	Petiau, Christophe [> > > >]
	Luxen, André [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
	Van der Linden, Martial [Université de Liège - ULg > Département des sciences cognitives > Psychopathologie cognitive >]
	Cleeremans, Axel [> > > >]
	Smith, C. [> > > >]
	Maquet, Pierre [Université de Liège - ULg > > Centre de recherches du cyclotron]
Publication date :	2001
Journal title :	Neuroscience
Publisher :	Pergamon-Elsevier Science
Volume :	105
Issue/season :	3
Pages :	521-525
Audience :	International
ISSN :	0306-4522
City :	Oxford
Keywords :	[en] Memory ; Brain plasticity ; Psychophysiological interaction analysis ; Functional neuroimaging ; Positron emission tomography
Abstract :	[en] One function of sleep is hypothesized to be the reprocessing and consolidation of memory traces (Smith, 1995; Gais et al., 2000; McGaugh, 2000; Stickgold et al., 2000). At the cellular level, neuronal reactivations during post-training sleep in animals have been observed in hippocampal (Wilson and McNaughton, 1994) and cortical (Amzica et al., 1997) neuronal populations. At the systems level, using positron emission tomography, we have recently shown that some brain areas reactivated during rapid-eye-movement sleep in human subjects previously trained on an implicit learning task (a serial reaction time task) (Maquet et al., 2000). These cortical reactivations, located in the left premotor area and bilateral cuneus, were thought to reflect the reprocessing - possibly the consolidation - of memory traces during post-training rapid-eye-movement sleep. Here, the experience-dependent functional connectivity of these brain regions is examined. It is shown that the left premotor cortex is functionally more correlated with the left posterior parietal cortex and bilateral pre-supplementary motor area during rapid-eye-movement sleep of subjects previously trained to the reaction time task compared to rapid-eye-movement sleep of untrained subjects. The increase in functional connectivity during post-training rapid-eye-movement sleep suggests that the brain areas reactivated during post-training rapid-eye-movement sleep participate in the optimization of the network that subtends subject's visuo-motor response. The optimization of this visuo-motor network during sleep could explain the gain in performance observed during the following day.
Permalink :	http://hdl.handle.net/2268/37678
	also: http://hdl.handle.net/2268/84575
DOI :	10.1016/S0306-4522(01)00269-X
Other URL :	http://www.elsevier.com/wps/find/journaldescription.cws_home/468/description#description

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