Article (Scientific journals)
Arguments for the presence of a Na-K ATPase pump inhibitor in the plasma of uremic and essential hypertensive patients
Krzesinski, Jean-Marie; Godon, Jean-Pierre; Rorive, Georges
1985In Clinical and Experimental Hypertension. Part A, Theory and Practice
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Keywords :
-K pump inhibitor; natriuretic factor; uremia; essential hypertension
Abstract :
[en] The effect of salt and/or volume depletion has been tested in 6 end-stage renal disease and 11 essential hypertensive patients (HTA) on red blood cell (RBC) ionic fluxes. Volume depletion promotes an increase in the RBC Na-K ATPase activity with, as a result, a significant decrease in intracellular sodium concentration ((Na)ic). Moreover, a factor has been found in the plasma of uremic subjects which causes natriuresis when injected in rat renal arteries. The concentration of this factor decreases during dialysis in relation to the weight loss and the increase in the RBC Na-K pump activity. In essential hypertension, the effect of a low salt diet on the blood pressure is correlated with the improvement of RBC Na-K ATPase activity. These experiments illustrate the presence of a Na-K ATPase inhibitor in the plasma of these subjects, dependent on sodium and water balance.
Disciplines :
Urology & nephrology
Author, co-author :
Krzesinski, Jean-Marie ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Godon, Jean-Pierre;  Université de Liège - ULiège > Médecine Interne > Néphrologie
Rorive, Georges ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Language :
English
Title :
Arguments for the presence of a Na-K ATPase pump inhibitor in the plasma of uremic and essential hypertensive patients
Publication date :
1985
Journal title :
Clinical and Experimental Hypertension. Part A, Theory and Practice
ISSN :
0730-0077
Publisher :
Marcel Dekker, New York, United States - New York
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 May 2010

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