Reference : L'etude clinique du mois. United Kingdom Prospective Diabetes Study: 10 ans plus tard.
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Human health sciences : General & internal medicine
http://hdl.handle.net/2268/3761
L'etude clinique du mois. United Kingdom Prospective Diabetes Study: 10 ans plus tard.
French
[en] United Kingdom Prospective Diabetes Study (UKPDS): 10 years later
Scheen, André mailto [Université de Liège - ULg > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale >]
Paquot, Nicolas mailto [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques >]
Lefebvre, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques >]
2008
Revue Médicale de Liège
63
10
624-9
Yes (verified by ORBi)
0370-629X
Belgium
[en] Arterial hypertension ; Coronary heart disease ; HbA1c ; Microangiopathy ; Mortality ; Type 2 diabetes ; UKPDS
[en] A 10-year post-trial monitoring of patients with newly diagnosed type 2 diabetes randomised in the "United Kingdom Prospective Diabetes Study" (UKPDS) demonstrated a continued reduction in microvascular risk (-24%, p = 0.001) and emergent risk reductions for myocardial infarction (-15%, p = 0.01) and death from any cause (-13%, p = 0.007), despite an early loss of glycaemic differences ("legacy effect"). A continued benefit after metformin therapy was evident during the ten-year post-trial follow-up among overweight patients (-33%, p = 0.005 for myocardial infarction and -27%, p = 0.002 for death from any cause). In contrast, the benefits of previously improved blood pressure control were not sustained when between-groups differences in blood pressure were lost during follow-up, except for a reduced risk for peripheral vascular disease. These observations are strong arguments in favour of an early optimisation of blood glucose control and of a sustained control of blood pressure in patients with type 2 diabetes.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/3761
also: http://hdl.handle.net/2268/4175
http://www.rmlg.ulg.ac.be/index.php?page=resume?num_id=1800
http://www.rmlg.ulg.ac.be/

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
200810_09.pdfNo commentaryPublisher postprint589.41 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.