Reference : Molecular pathways of angiogenesis inhibition.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/37553
Molecular pathways of angiogenesis inhibition.
English
Tabruyn, Sébastien mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Griffioen, Arjan W [> > > >]
2007
Biochemical and Biophysical Research Communications
Academic Press
355
1
1-5
Yes (verified by ORBi)
International
0006-291X
1090-2104
San Diego
CA
[en] Angiogenesis Inhibitors/therapeutic use ; Angiostatins/therapeutic use ; Apoptosis/drug effects ; Autoantigens/therapeutic use ; Cell Cycle/drug effects ; Cell Division/drug effects ; Cell Survival/drug effects ; Collagen Type IV/therapeutic use ; Endostatins/therapeutic use ; Humans ; Matrix Metalloproteinase 2/antagonists & inhibitors ; Neovascularization, Pathologic/prevention & control ; Platelet Factor 4/therapeutic use ; Thrombospondin 1/therapeutic use
[en] A large body of evidence now demonstrates that angiostatic therapy represents a promising way to fight cancer. This research recently resulted in the approval of the first angiostatic agent for clinical treatment of cancer. Progress has been achieved in decrypting the cellular signaling in endothelial cells induced by angiostatic agents. These agents predominantly interfere with the molecular pathways involved in migration, proliferation and endothelial cell survival. In the current review, these pathways are discussed. A thorough understanding of the mechanism of action of angiostatic agents is required to develop efficient anti-tumor therapies.
http://hdl.handle.net/2268/37553
also: http://hdl.handle.net/2268/37556
10.1016/j.bbrc.2007.01.123

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