Executive dysfunction in Alzheimer's disease

[en] Executive functioning was examined in 20 patients with Alzheimer's disease (AD) and 20 normal elderly subjects. The results showed that AD patients present lower performance compared to control subjects in all executive tasks, confirming that some executive deficits may be present in the first stages of the disease. A factorial analysis suggested that these deficits can be related to two domains of the executive functions: the inhibition abilities and the capacity to co-ordinate simultaneously storage and processing of information. Moreover, the performance on these factors is correlated to different anterior and posterior cortical areas.

Disciplines :

Neurosciences & behavior

Author, co-author :

Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie

Van der Linden, Martial ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive

Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.

Language :

English

Title :

Executive dysfunction in Alzheimer's disease

Publication date :

1999

Journal title :

Cortex: A Journal Devoted to the Study of the Nervous System and Behavior

ISSN :

0010-9452

eISSN :

1973-8102

Publisher :

Masson, Milano, Italy

Volume :

Issue :

Pages :

57-72

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.elsevier.com/wps/find/journaldescription.cws_home/714334/description#description

Available on ORBi :

since 14 March 2011

Statistics

Number of views

285 (23 by ULiège)

Number of downloads

1420 (9 by ULiège)

More statistics

Scopus citations^®

164

Scopus citations^®
without self-citations

148

OpenCitations

111

Bibliography

BADDELEY, A.D., Human Memory: Theory and Practive. Hove: Erlbaum, 1990.
BADDELEY, A.D., BRESSI, S., DELLA SALA, S., LOGIE, R., and SPINNLER, H. The decline of working memory in Alzheimer's disease. A longitudinal study. Brain, 114: 2521-2542, 1991.
BADDELEY, A.D., DELLA SALA, S., PAPAGNO, C., and SPINNLER, H. Dual-task performance in dysexecutive and nondysexecutive patients with a frontal lesion. Neuropsychology, 11: 187-194, 1997.
BADDELEY, A.D., LEWIS, V., ELDRIDGE, M., and THOMSON, N. Attention and retrieval from long-term memory. Journal of Experimental Psychology: General, 113: 518-540, 1984.
BADDELEY, A.D., LOGIE, R., BRESSI, S., DELLA SALA, S., and SPINNLER, H. Dementia and working memory. The Quarterly Journal of Experimental Psychology, 38A: 603-618, 1986.
BECKER, J.T. Working memory and secondary memory deficits in Alzheimer's disease. Journal of Clinical and Experimental Neuropsychology, 10: 739-753, 1988.
BELLEVILLE, S., ROULEAU, N., and CAZA, N. Effects of normal aging on the manipulation of information in working memory. Memory and Cognition, 26: 572-583, 1998.
BENCH, C.J., FRITH, C.D., GRASBY, P.M., FRISTON, K.J., PAULESU, E., FRACKOWIAK, R.S.J., and DOLAN, R.J. Investigations of the functional anatomy of attention using the Stroop Test. Neuropsychologia, 31: 907-922, 1993.
BHUTANI, G.E., MONTALDI, D., BROOKS, D.N., and MCCULLOCH, J. A neuropsychological investigation into frontal lobe involvement in dementia of the Alzheimer type. Neuropsychology, 6: 211-224, 1992.
BINETTI, G., MAGNI, E., PADOVANI, A., CAPPA, S.F., BIANCHETTI, A., and TRABUCCHI, M. Executive dysfunction in early Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 60: 91-93, 1996.
BRUGGER, P., MONSCH, A.U., SALMON, D.P., and BUTTERS, N. Random number generation in dementia of the Alzheimer type: A test of frontal executive functions. Neuropsychologia, 34: 97-103, 1996.
BURGESS, P.W., and SHALLICE, T. Response suppression, initiation and strategy use following frontal lobe lesions. Neuropsychologia, 34: 263-273, 1996.
BURGESS, P.W., and SHALLICE, T. Fractionnement du syndrome frontal. Revue de Neuropsychologie, 4: 345-370, 1994.
CHERTKOW, H., and BUB, D. Semantic memory loss in dementia of the Alzheimer's type. Brain, 113: 397-417, 1990.
COLLETTE, F., VAN DER LINDEN, M., BECHET, S., BELLEVILLE, S., and SALMON, E. Working memory deficits in Alzheimer's disease. Brain and Cognition, 37: 147-149, 1998.
DARYN, E. Hukok Logical Thinking Matrices Test. Tel Aviv: Eked, 1997.
D'ESPOSITO, M., DETRE, J.A., ALSOP, C.D., SHIN, R.K., ATLAS, S., and GROSSMAN, M. The neural basis of the central executive of working memory. Nature, 378: 279-281, 1995.
D'ESPOSITO, M., and GROSSMAN, M. The physiological basis of executive function and working memory. The Neuroscientist, 2: 345-352, 1996.
DIAMOND, A. Neuropsychological insights into the meaning of object concept development. In M.H. Johnson (Ed.), Brain Development and Cognition. A Reader. Oxford: Basic Blackwell, 1993, pp. 208-247.
FREEDMAN, M., and OSCAR-BERMAN, M. Bilateral frontal lobe disease and selective DR deficits in humans. Behavioral Neuroscience, 100: 337-342, 1986.
FRISTON, K.J., HOLMES, A.P., WORSLEY, K.J., POLINE, J.-B., FRITH, C.D., and FRACKOWIAK, R.S.J. Statistical parametric maps in functional imaging: A general linear approach. Human Brain Mapping, 2: 189-210, 1995.
FUSTER, J.M. Frontal lobes. [Review]. Current Opinion in Neurobiology, 3: 160-165, 1993.
GOLDMAN-RAKIC, P. Circuitry of the prefrontal cortex and the regulation of behavior by representational knowledge. In F. Plum and V. Mountcastle (Eds.), Handbook of Physiology. Bethesda, MD: American Physiological Society, 1987, pp. 373-417.
GRADY, C.L., and HAXBY, J.V. Functional neuroimaging of the aging brain. In J.C. Baron (Ed.), Handbook of Neuropsychology (Vol. 10). Amsterdam: Elsevier, 1995, pp. 467-481.
GREENE, J.D.W., HODGES, J.R., and BADDELEY, A.D. Autobiographical memory and executive functions in early dementia of Alzheimer type. Neuropsychologia, 33: 1647-1670, 1995.
HOUDÉ, O. Erreur A-non-B, inhibition et cortex préfrontal: une articulation des analyses. Revue de Neuropsychologie, 6: 329-346, 1996.
KENNEDY, A.M., and FRACKOWIAK, R.S.J. Positron emission tomography. In A. Burns and R. Levy (Eds.), Dementia. London: Chapman and Hall, 1994, pp. 457-474.
LAFLECHE, G., and ALBERT, M.S. Executive function deficits in mild Alzheimer's disease. Neuropsychology, 9: 313-320, 1995.
MACK, J.L., and PATTERSON, M.B. Executive dysfunction and Alzheimer's disease: Performance on a test of planning ability, the Porteus Maze Test. Neuropsychology, 9: 556-564, 1995.
MATTIS, S. Dementia Rating Scale. Windsor: NFER-Nelson, 1973.
MCKHANN, G., DRACHMAN, D., FOLSTEIN, M., KATZMAN, R., PRICE, D., and STADLAN, E.M. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology, 34: 939-944, 1984.
MONSCH, A.U., BONDI, M.W., SALMON, D.P., BUTTERS, N., THAL, L.J., HANSEN, L.A., WIEDERHOLT, W.C., CAHN, D.A., and KLAUBER, M.R. Clinical validity of the Mattis dementia rating scale in detecting dementia of the Alzheimer type. Archives of Neurology, 52: 899-904, 1995.
MORRIS, R.G. Recent developments in the neuropsychology of dementia. International Review of Psychiatry, 6: 85-107, 1994a.
MORRIS, R.G. Working memory in Alzheimer-type dementia. Neuropsychology, 8: 544-554, 1994b.
MORRIS, R.G. Neurobiological correlates of cognitive dysfunction. In R.G. Morris (Ed.), The Cognitive Neuropsychology of Alzheimer-Type Dementia. Oxford: Oxford University Press, 1996, pp. 223-254.
NESTOR, P.G., PARASURAMAN, R., and HAXBY, J.V. Speed of information processing and attention in early Alzheimer's dementia. Developmental Neuropsychology, 7: 243-256, 1991.
NYBERG, L., CABEZA, R., and TULVING, E. PET studies of encoding and retrieval: The HERA model. Psychonomic Bulletin and Review, 3: 135-148, 1996.
PASQUIER, F., LEBERT, F., GRYMONPREZ, L., and PETIT, H. Verbal fluency in dementia of frontal lobe type and dementia of Alzheimer type. Journal of Neurology, Neurosurgery and Psychiatry, 58: 81-84, 1995.
PASSINI, R., RAINVILLE, C., MARCHAND, N., and JOANETTE, Y. Way finding in dementia of the Alzheimer type: Planning abilities. Journal of Clinical and Experimental Neuropsychology, 17: 820-832, 1995.
PAULESU, E., FRITH, C.D., and FRACKOWIAK, R.S.J. The neural correlates of the verbal component of working memory. Nature, 362: 342-345, 1993.
PERRET, E. The left frontal lobe of man and the suppression of habitual responses in verbal categorical behavior. Neuropsychologia, 12: 323-330, 1974.
PETRIDES, M., ALIVASTOS, B., MEYER, E., and EVANS, A.C. Functional activation of the human frontal cortex during the performance of verbal working memory tasks. Proceedings of the National Academic of Sciences, USA, 90: 878-882, 1993.
PETRIDES, M., and MILNER, B. Deficits in subject-ordered tasks after frontal and temporal lobe lesions in man. Neuropsychologia, 20: 249-262, 1982.
PILLON, B., DUBOIS, B., LHERMITTE, F., and AGID, Y. Heterogeneity of cognitive impairment in progressive supranuclear palsy, Parkinson's disease and Alzheimer's disease. Neurology, 36: 1179-1185, 1986.
RAINVILLE, C., FABRIGOULE, C., AMIEVA, H., LAFONT, S., and DARTIGUES, J.F. Problem solving deficits in patients with dementia of the Alzheimer's type on a Tower of London task. Brain and Cognition, 37: 135-136, 1998.
RANDOLPH, C., BRAUN, A.R., GOLDBERG, T.E., and CHASE, T.N. Semantic fluency in Alzheimer's, Parkinson's, and Huntington's disease: Dissociation of storage and retrieval failures. Neuropsychology, 7: 82-88, 1993.
SALMON, E., SADZOT, B., MAQUET, P., DEGUELDRE, C., LEMAIRE, C., RIGO, P., COMAR, D., and FRANCK, G. Differential diagnosis of Alzheimer's disease with PET. Journal of Nuclear Medicine, 35: 391-398, 1994.
SALMON, E., VAN DER LINDEN, M., COLLETTE, F., DELFIORE, G., MAQUET, P., DEGUELDRE, C., LUXEN, A., and FRANCK, G. Regional brain activity during working memory tasks. Brain, 119: 1617-1625, 1996.
SALTHOUSE, T.A., and BABCOCK, R.L. Decomposing adult age differences in working memory. Developmental Psychology, 27: 763-776, 1991.
SHALLICE, T. From Neuropsychology to Mental Structures. Cambridge: Cambridge University Press, 1988.
SHALLICE, T. Multiple levels of control processes. In C. Umiltà and M. Moscovitch (Eds.), Attention and Performance, XV. Conscious and Nonconscious Information Processing. Cambridge: A Bradford Book/The MIT Press, 1994, pp. 395-420.
SHALLICE, T., and BURGESS, P.W. Supervisory control of action and thought selection. In A.D. Baddelety and L. Weiskrantz (Eds.), Attention: Selection, Awareness and Control: A Tribute to Donald Broadbent. Oxford: Oxford University Press, 1993, pp. 171-187.
SPIELER, D.H., BALOTA, D.A., and FAUST, M.E. Stroop performance in healthy younger and older adults and in individuals with dementia of the Alzheimer's type. Journal of Experimental Psychology, 22: 461-479, 1996.
SULLIVAN, M.P., FAUST, M.E., and BALOTA D.A. Identity negative priming in older adults and in individuals with dementia of the Alzheimer type. Neuropsychology, 9: 537-555, 1995.
TAYLOR, S.F., KORNBLUM, S., LAUBER, E.J., MINOSHIMA, S., and KOEPPE, R.A. Isolation of specific interference processing in the Stroop task: PET activation studies. Neuroimage, 6: 81-92, 1997.
TROYER, A.K., MOSCOVITCH, M., WINOCUR, G., LEACH, L., and FREEDMAN, M. Clustering and switching on verbal fluency tests in Alzheimer's and Parkinson's disease. Journal of the International Neuropsychological Society, 4: 137-143, 1998.
WALDEMAR, G., BRUHN, P., KRISTENSEN, M., JOHNSEN, A., PAULSON, O.B., and LASSEN, N.A. Heterogeneity of neocortical cerebral blood flow deficits in dementia of the Alzheimer type: A [99mTc]-d,l-HMPAO SPECT study. Journal of Neurology, Neurosurgery and Psychiatry, 57: 285-295, 1994.
WEINBERGER, D.R. A connectionist approach to the prefrontal cortex. The Journal of Neuropsychiatry and Clinical Neurosciences, 5: 241-253, 1993.