Reference : Intratumoral heterogeneity for hsp90 mRNA levels in a breast cancer cell line
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/37350
Intratumoral heterogeneity for hsp90 mRNA levels in a breast cancer cell line
English
Luparello, C. [ > > ]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Pucci-Minafra, I. [ > > ]
1997
DNA & Cell Biology
Mary Ann Liebert, Inc.
16
1231-1236
Yes (verified by ORBi)
International
1044-5498
1557-7430
Larchmont
NY
[en] BC-3A and BC-61 are two breast cancer cell lines that have been cloned from parental 8701-BC cells and exhibit different biosynthetic, proliferative, and invasive properties in vitro. In the attempt to search whether alterations in the profiles of gene expression could be detected, we have submitted both cytotypes to identification of differentially expressed cDNAs. In addition, steroid hormone receptor mRNA arrays and in vivo tumorigenesis of the two lines have been checked. The technique used allowed identification of changes in the expression of the 90-kD heat shock protein-beta (hsp90beta) which is prominently down-regulated in BC-61 cells. Because we have also found that these cells, which lack estrogen receptor mRNA synthesis, display a more invasive behavior in vitro and increased tumorigenesis in vivo, we propose that evaluation of hsp903 transcript levels may be taken into consideration for screening as a novel molecular marker of breast cancer progression.
http://hdl.handle.net/2268/37350

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Luparello DNA .1997.pdfPublisher postprint460.14 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.