Reference : Synthesis and antimitotic effects of isoretulinal, a main alkaloid isolated from Strychn...
Scientific journals : Short communication
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/37293
Synthesis and antimitotic effects of isoretulinal, a main alkaloid isolated from Strychnos variabilis
English
Tits, Monique mailto [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
Bassleer, Roger [ > > ]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
1990
Journal de Pharmacie de Belgique
Nationale Pharmaceutique
45
6
393
Yes (verified by ORBi)
International
0047-2166
Bruxelles
Belgique
[en] Strychnos variabilis ; isoretulinal ; synthesis ; antimitotic activity ; analgesic activity ; LD 50 ( mice)
[en] Isoretulinal is a new alkaloid isolated from Strychnos variabilis rootbark. It can also be easily prepared by oxydation of isoretuline. This alkaloid shows an antimitotic effect at a dose of 10 micrograms/ml on different strains of cancer cells. Moreover isoretulinal possesses an analgesic activity. However this alkaloid is sixty-fold less toxic than strychnine (intravenous acute toxicity in mice).
http://hdl.handle.net/2268/37293

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