Short communication (Scientific journals)
Synthesis and antimitotic effects of isoretulinal, a main alkaloid isolated from Strychnos variabilis
Tits, Monique; Bassleer, Roger; Angenot, Luc
1990In Journal de Pharmacie de Belgique, 45 (6), p. 393
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Keywords :
Strychnos variabilis; isoretulinal; synthesis; antimitotic activity; analgesic activity; LD 50 ( mice)
Abstract :
[en] Isoretulinal is a new alkaloid isolated from Strychnos variabilis rootbark. It can also be easily prepared by oxydation of isoretuline. This alkaloid shows an antimitotic effect at a dose of 10 micrograms/ml on different strains of cancer cells. Moreover isoretulinal possesses an analgesic activity. However this alkaloid is sixty-fold less toxic than strychnine (intravenous acute toxicity in mice).
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Tits, Monique ;  Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Bassleer, Roger ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Synthesis and antimitotic effects of isoretulinal, a main alkaloid isolated from Strychnos variabilis
Publication date :
1990
Journal title :
Journal de Pharmacie de Belgique
ISSN :
0047-2166
Publisher :
Nationale Pharmaceutique, Bruxelles, Belgium
Volume :
45
Issue :
6
Pages :
393
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 May 2010

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