[en] Isoretulinal is a new alkaloid isolated from Strychnos variabilis rootbark. It can also be easily prepared by oxydation of isoretuline. This alkaloid shows an antimitotic effect at a dose of 10 micrograms/ml on different strains of cancer cells. Moreover isoretulinal possesses an analgesic activity. However this alkaloid is sixty-fold less toxic than strychnine (intravenous acute toxicity in mice).
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Tits, Monique ; Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Bassleer, Roger ; Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Synthesis and antimitotic effects of isoretulinal, a main alkaloid isolated from Strychnos variabilis