Reference : Synthesis and antimitotic effects of isoretulinal, a main alkaloid isolated from Strychn...

	Document type :	Scientific journals : Short communication
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology
	To cite this reference:	http://hdl.handle.net/2268/37293

Title :	Synthesis and antimitotic effects of isoretulinal, a main alkaloid isolated from Strychnos variabilis
Language :	English
Author, co-author :	Tits, Monique [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
	Bassleer, Roger [ > > ]
	Angenot, Luc [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Publication date :	1990
Journal title :	Journal de Pharmacie de Belgique
Publisher :	Nationale Pharmaceutique
Volume :	45
Issue/season :	6
Pages :	393
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0047-2166
City :	Bruxelles
Country :	Belgique
Keywords :	[en] Strychnos variabilis ; isoretulinal ; synthesis ; antimitotic activity ; analgesic activity ; LD 50 ( mice)
Abstract :	[en] Isoretulinal is a new alkaloid isolated from Strychnos variabilis rootbark. It can also be easily prepared by oxydation of isoretuline. This alkaloid shows an antimitotic effect at a dose of 10 micrograms/ml on different strains of cancer cells. Moreover isoretulinal possesses an analgesic activity. However this alkaloid is sixty-fold less toxic than strychnine (intravenous acute toxicity in mice).
Permalink :	http://hdl.handle.net/2268/37293

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	Fulltext file(s): File Commentary Version Size Access Restricted access J. Pharm. Belg. 1990 _ 45 _ 6 p 393.pdf Publisher postprint 61.88 kB Request copy

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