Reference : Role de l'inhibiteur des activateurs de plasminogene de type 1 dans l'angiogenese tumorale
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/63568
Role de l'inhibiteur des activateurs de plasminogene de type 1 dans l'angiogenese tumorale
French
[en] Role of Plasminogen Activator Inhibitor Type 1 in Tumor Angiogenesis
Bajou, Khalid mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie et génétique moléculaire >]
Devy, L. [> > > >]
Masson, Véronique [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
Albert, V. [> > > >]
Frankenne, Francis [> >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
2001
Thérapie
EDP Sciences
56
5, Sep-Oct
465-72
Yes (verified by ORBi)
International
0040-5957
Les Ulis
France
[en] Tumor invasion ; Angiogenesis ; PAI-1
[en] The plasminogen/plasmin system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumour cell migration. High levels of components of the plasminogen activation system, and paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI-1), have been correlated with a poor prognosis for patients with cancers of different types. Recent findings clearly suggest that PAI-1 is essential for capillary sprouting during tumour angiogenesis. Moreover, there is accumulating evidence that both the urokinase receptor and PAI-1 are multifunctional proteins involved not only in extracellular matrix proteolysis but also in cellular adhesion and migration through their binding site for vitronectin. The understanding of whether PAI-1 plays a regulatory role in angiogenesis by tightly controlling proteolytic activity or by influencing cell migration could allow a new anti-angiogenic approach for tumour therapy.
http://hdl.handle.net/2268/63568
also: http://hdl.handle.net/2268/37286

There is no file associated with this reference.

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.