Reference : Etude complémentaire de la cytotoxicite de la mélinonine F, alcaloide dérive de la beta-...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/37275
Etude complémentaire de la cytotoxicite de la mélinonine F, alcaloide dérive de la beta-carboline
French
[en] Complementary Study of Cytotoxic Activity of Melinonine F.
Bassleer, Roger [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]
Marnette, J. M. [> > > >]
Wiliquet, P. [> > > >]
Gillet, Marie-Claire mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques >]
Caprasse, M. [> > > >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Nov-1983
Planta Medica
49
11
158-161
International
0032-0943
[en] Strychnos melinoniana ; Strychnos usambarensis ; melinonine F ; cancer cells ; DNA intercalation
[en] The cellular effects of melinonine F, an alkaloid isolated from STRYCHNOS MELINONIANA (South America) and STRYCHNOS USAMBARENSIS (Central Africa), are analysed in cancer or normal cells in culture. A cytotoxic action is noted in both types of cells, at least for relatively high concentrations. These effects are probably due to interaction of the drug with chromatin. Physico-chemical analysis demonstrates partial intercalation of melinonine F on pure DNA IN VITRO.
http://hdl.handle.net/2268/37275

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