Article (Scientific journals)
Cardiovascular haemodynamics and ventriculo-arterial coupling in an acute pig model of coronary ischaemia-reperfusion
Lanoye, Lieve; Segers, Patrick; Tchana-Sato, Vincent et al.
2007In Experimental Physiology, 92 (1), p. 127-137
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Abstract :
[en] Although reperfusion after coronary occlusion is mandatory for myocardial salvage, reperfusion may trigger a cascade of harmful events (reperfusion injury) adding to myocardial injury. We investigated effects of reperfusion on left ventricular (LV) haemodynamics and ventriculo-arterial (VA) coupling in pigs following acute myocardial ischaemia induced by coronary artery occlusion. Experiments were performed in six animals, with measurements of cardiac and arterial function at baseline, after 60 min of ischaemia (T60) and after 2 (T180) and 4 h of reperfusion (T300). Ventriculo-arterial coupling was assessed using the ventriculo-arterial elastance ratio of paper, as well as using a 'stiffness coupling' and 'temporal coupling' index. Reperfusion following ischaemia (T180 versus T60) induced a progressive decline in cardiovascular function, evidenced by a decrease in mean arterial blood pressure, cardiac output and ejection fraction which was not restored at T300. Although reperfusion also induced an increase in slope of the end-systolic pressure-volume relationship (ESPVR), the ESPVR curve shifted to the right, associated with a depression of contractile function. Histology demonstrated irreversible myocardial damage at T300. The ventriculo-arterial elastance ratio and the 'stiffness coupling' index were unaffected throughout the protocol, but the 'temporal coupling' parameter indicated a relative shift between heart period and the time constant of the arterial system. It is unlikely that these alterations are attributable to ischaemic injury alone. The combination of both the stiffness and temporal coupling index may provide more information when studying ventriculo-arterial coupling than the more commonly used ventricular end-systolic stiffness/effection arterial elastance (E-es/E-a) ratio.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Lanoye, Lieve;  Ghent University > Institute Biomedical Technology > Cardiovascular Mechanics and Biofluid Dynamics
Segers, Patrick;  Ghent University > Institute Biomedical Technology > Cardiovascular Mechanics and Biofluid Dynamics
Tchana-Sato, Vincent  ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire
Rolin, Stéphanie;  University of Namur > Department of Pharmacy
Dogné, Jean-Michel ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Ghuysen, Alexandre ;  Université de Liège - ULiège > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière
Lambermont, Bernard  ;  Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine
Hanson, Julien  ;  Université de Liège - ULiège > Chimie pharmaceutique
Desaive, Thomas  ;  Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Verdonck, Pascal;  Ghent University > Institute Biomedical Technology > Cardiovascular Mechanics and Biofluid Dynamics
D'Orio, Vincenzo ;  Université de Liège - ULiège > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path.
Kolh, Philippe  ;  Université de Liège - ULiège > Services généraux (Fac. de psycho. et des sc. de l'éducat.) > Relations académiques et scientifiques (Psycho et sc.éduc.) - Relations académiques et scientifiques (Sciences)
Language :
English
Title :
Cardiovascular haemodynamics and ventriculo-arterial coupling in an acute pig model of coronary ischaemia-reperfusion
Publication date :
01 January 2007
Journal title :
Experimental Physiology
ISSN :
0958-0670
eISSN :
1469-445X
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
92
Issue :
1
Pages :
127-137
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 06 January 2009

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