Article (Scientific journals)
Red Blood Cell Na-Li Countertransport, Hypertensive Heredity, and Cardiovascular Risk in Young Adults
Krzesinski, Jean-Marie; Saint-Remy, Annie; Du, F. et al.
1993In American Journal of Hypertension, 6 (4), p. 314-316
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Keywords :
Na-Li countertransport; Family history of hypertension; Plasma lipids; Blood pressure; Weigh
Abstract :
[en] The erythrocyte Na-Li countertransport (CT) has been considered as a marker of genetic propension to essential hypertension, but also to be linked to atherosclerosis risk factors. We have evaluated these relationships by measuring the Na-Li CT, blood pressure levels, the family predisposition to hypertension, body mass index, subscapular skin-fold thickness, waist/hip ratio, and plasma lipids in 43 young adults (22 to 23 years; 13 with a positive family history of hypertension), followed since adolescence (+/- 10 years) to analyze the natural history of blood pressure in this period of life. The Na-Li CT was negatively correlated with the HDL cholesterol (r = -0.37) and the HDL cholesterol/total cholesterol ratio (r = -0.44). This transport system was positively correlated to family history of hypertension (r = 0.38), waist/hip ratio, and the diastolic blood pressure. When the family history of hypertension was present, Na-Li CT and diastolic blood pressure were higher (P < .05), but the HDL cholesterol was lower (P < .01). After separating people according to the blood pressure level during adolescence in two groups, one lower than the 75th percentile (P75), and one higher, we notice that the latter remains characterized by a higher systolic blood pressure. But neither the Na-Li CT nor family history of hypertension and plasma lipids could explain the difference in the blood pressure behavior during this period. Thus, an increase of RBC Na-Li CT activity in young adults would suggest a higher cardiovascular risk rather than to be a simple marker of a hypertensive risk.
Disciplines :
Urology & nephrology
Author, co-author :
Krzesinski, Jean-Marie ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Saint-Remy, Annie ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
Du, F.
Rorive, Georges ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Language :
English
Title :
Red Blood Cell Na-Li Countertransport, Hypertensive Heredity, and Cardiovascular Risk in Young Adults
Publication date :
1993
Journal title :
American Journal of Hypertension
ISSN :
0895-7061
eISSN :
1941-7225
Publisher :
Oxford University Press, United Kingdom
Volume :
6
Issue :
4
Pages :
314-316
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
This article is based on data presented at the American Society of Hypertension's annual meeting May 6 to 9, 1992.
Available on ORBi :
since 18 May 2010

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