Reference : Impact of mitral regurgitation and myocardial viability on left ventricular reverse remo...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
Human health sciences : General & internal medicine
http://hdl.handle.net/2268/36995
Impact of mitral regurgitation and myocardial viability on left ventricular reverse remodeling after cardiac resynchronization therapy in patients with ischemic cardiomyopathy.
English
Senechal, Mario [Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada > Département de cardiologie > > >]
Lancellotti, Patrizio mailto [Université de Liège - ULg > Département des sciences cliniques > Imagerie cardiaque fonctionnelle par échographie >]
Magne, Julien mailto [Université de Liège - ULg > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation >]
Garceau, Patrick [Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada > Département de cardiologie > > >]
Champagne, Jean [Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada > Département de cardiologie > > >]
Philippon, Francois [Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada > Département de cardiologie > > >]
O'Hara, Gilles [Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada > Département de cardiologie > > >]
Moonen, Marie mailto [Université de Liège - ULg > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation >]
Dubois, Michelle [Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada > Département de cardiologie > > >]
1-Jul-2010
American Journal of Cardiology
Elsevier Science
106
1
31-7
Yes (verified by ORBi)
International
0002-9149
New York
NY
[en] Aged ; Aged, 80 and over ; Cardiac Pacing, Artificial ; Cardiomyopathies/complications/therapy ; Female ; Humans ; Male ; Middle Aged ; Mitral Valve Insufficiency/complications ; Pacemaker, Artificial ; Sensitivity and Specificity ; Severity of Illness Index ; Ventricular Remodeling
[en] This study investigated the impact of ischemic mitral regurgitation (MR) severity and viability on left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT) in patients with ischemic cardiomyopathy. Severe MR and ischemic cardiomyopathy have been associated with lack of LV reverse remodeling after CRT. Fifty-seven consecutive patients with ischemic MR, LV ejection fraction < or =35%, QRS duration > or =120 ms, and intraventricular dyssynchrony > or =50 ms were prospectively included. Stress echocardiography was performed before CRT implantation. Viability in the region of the LV pacing lead was defined as the presence of viability in 2 contiguous segments. Response to CRT at 6 months was defined by evidence of > or =15% LV decrease in end-systolic volume. Severe MR was defined by an effective regurgitant orifice (ERO) area > or =20 mm(2). Thirty-three patients (58%) were responders at follow-up. Baseline ERO area and prevalence of severe MR were not different between responders and nonresponders (19 +/- 11 vs 21 +/- 13 mm(2), p = 0.67; 52% vs 53%, p = 0.84). In responders, MR was decreased by 58% (ERO 19 +/- 12 to 8 +/- 6 mm(2)). In the presence of viability in the region of the pacing lead, 74% (n = 29 patients) were responders (sensitivity 88%, specificity 58%); in the subgroup of patients with viability in the region of the pacing lead and severe MR, 83% (n = 17 patients) were responders. In conclusion, LV remodeling is frequent and ischemic MR decrease important in patients with viability in the region of the pacing lead without regard to MR severity.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals
http://hdl.handle.net/2268/36995
also: http://hdl.handle.net/2268/140760
10.1016/j.amjcard.2010.02.012
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T10-502V3CX-3&_user=532038&_coverDate=07%2F01%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000026659&_version=1&_urlVersion=0&_userid=532038&md5=4c6facc01b0a4420be9bb45919f766b6&searchtype=a
Copyright (c) 2010 Elsevier Inc. All rights reserved.

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