Reference : Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elo...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/3687
Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells.
English
Cornez, Isabelle [Université de Liège - ULg > > Chimie médicale >]
Creppe, Catherine mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Gillard, Magali [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Hennuy, Benoît mailto [Université de Liège - ULg > > GIGA-Management : Plate-forme transcriptomique >]
Chapelle, Jean-Paul mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Dejardin, Emmanuel mailto [Université de Liège - ULg > > Virologie - Immunologie >]
Merville, Marie-Paule mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Close, Pierre mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Jun-2008
Biochemical Pharmacology
Elsevier Science
75
2122-2134
Yes (verified by ORBi)
International
0006-2952
Oxford
United Kingdom
[en] Elongator ; p53 ; transcription
[en] Elongator, a multi-subunit complex assembled by the IkappaB kinase-associated protein (IKAP)/hELP1 scaffold protein is involved in transcriptional elongation in the nucleus as well as in tRNA modifications in the cytoplasm. However, the biological processes regulated by Elongator in human cells only start to be elucidated. Here we demonstrate that IKAP/hELP1 depleted colon cancer-derived cells show enhanced basal expression of some but not all pro-apoptotic p53-dependent genes such as BAX. Moreover, Elongator deficiency causes increased basal and daunomycin-induced expression of the pro-survival serum- and glucocorticoid-induced protein kinase (SGK) gene through a p53-dependent pathway. Thus, our data collectively demonstrate that Elongator deficiency triggers the activation of p53-dependent genes harbouring opposite functions with respect to apoptosis.
Giga-Signal Transduction
FNRS, TELEVIE, FBC, ARC ULG, PAI
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/3687

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