Article (Scientific journals)
Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells.
Cornez, Isabelle; Creppe, Catherine; Gillard, Magali et al.
2008In Biochemical Pharmacology, 75, p. 2122-2134
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Keywords :
Elongator; p53; transcription
Abstract :
[en] Elongator, a multi-subunit complex assembled by the IkappaB kinase-associated protein (IKAP)/hELP1 scaffold protein is involved in transcriptional elongation in the nucleus as well as in tRNA modifications in the cytoplasm. However, the biological processes regulated by Elongator in human cells only start to be elucidated. Here we demonstrate that IKAP/hELP1 depleted colon cancer-derived cells show enhanced basal expression of some but not all pro-apoptotic p53-dependent genes such as BAX. Moreover, Elongator deficiency causes increased basal and daunomycin-induced expression of the pro-survival serum- and glucocorticoid-induced protein kinase (SGK) gene through a p53-dependent pathway. Thus, our data collectively demonstrate that Elongator deficiency triggers the activation of p53-dependent genes harbouring opposite functions with respect to apoptosis.
Research center :
Giga-Signal Transduction - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Cornez, Isabelle ;  Université de Liège - ULiège > Chimie médicale
Creppe, Catherine ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Gillard, Magali ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Hennuy, Benoît ;  Université de Liège - ULiège > GIGA-Management : Plate-forme transcriptomique
Chapelle, Jean-Paul ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Dejardin, Emmanuel ;  Université de Liège - ULiège > Virologie - Immunologie
Merville, Marie-Paule ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Close, Pierre  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Chariot, Alain ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells.
Publication date :
June 2008
Journal title :
Biochemical Pharmacology
ISSN :
0006-2952
eISSN :
1873-2968
Publisher :
Elsevier Science, Oxford, United Kingdom
Volume :
75
Pages :
2122-2134
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FNRS, TELEVIE, FBC, ARC ULG, PAI
Available on ORBi :
since 06 January 2009

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