Reference : Development and validation of a quantitative method for the selective determination of t...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/3686
Development and validation of a quantitative method for the selective determination of tin species in tin octoate by differential pulse polarography
English
Hubert, Cédric [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
Ziemons, Eric mailto [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
Rozet, Eric [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
Breuer, Arnaud [Université de Liège - ULG > Pharmacie > Chimie Analytique > >]
Lambert, Abigail [Université de Liège - ULG > Pharmacie > Chimie Analytique > >]
Jasselette, Christophe [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
De Bleye, Charlotte [Université de Liège - ULg > > > 1re an. master sc. pharma., à finalité]
Lejeune, Robert [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
Hubert, Philippe [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
Jan-2010
Talanta
Elsevier Science
80
3
1413-1420
Yes (verified by ORBi)
International
0039-9140
Amsterdam
The Netherlands
[en] Speciation ; Stannous ; Stannic ; Tin octoate ; Differential pulse polarography ; DPP
[en] Tin octoate is used as a catalyst in the synthesis of polydimethylsiloxane (PDMS), a room temperature vulcanizing (RTV) silicone rubber. This rubber is largely used in the medical field due to its great biocompatibility. In this framework, a high-speed and costless analytical method for the determination of stannic ions, Sn(IV), in the presence of stannous ions, Sn(II), has been developed.

The separation of these two ions was carried out using differential pulse polarography (DPP). For this purpose, the tin species contents in the catalyst is quantitatively extracted under inert condition to avoid any changes in the ratio Sn(IV)/Sn(II). Polarography showed well-shaped oxidation and reduction peaks respectively at −650 and −860 mV for stannous ions. The peak of the stannic ion was well separated and appeared at −1210 mV. Many parameters such as extraction process, extraction time, pH, chelating agents and polarographic conditions were optimized. We have also demonstrated that no oxidation of the stannous ions occurred during the sample preparation.

The dosing range considered in this study extends between 10 and 40 μg/mL, corresponding to 6.8% and 27.2% of the degradation product (Sn(IV)) in the catalyst, regarding to the sampling. Finally this method was successfully validated using the total error concept.
CIRM
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/3686
10.1016/j.talanta.2009.09.045
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6THP-4XC9SBK-1&_user=532038&_coverDate=01%2F31%2F2010&_rdoc=57&_fmt=high&_orig=browse&_srch=doc-info%28%23toc%235288%232010%23999199996%231577368%23FLA%23display%23Volume%29&_cdi=5288&_sort=d&_docanchor=&_ct=66&_acct=C000026659&_version=1&_urlVersion=0&_userid=532038&md5=d5a0c00a932f5c0bda5bbe96b666eb8b
C. Hubert and E. Ziémons contributed equally to this work.

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