Reference : Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI ver...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/36811
Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus nanometer resolution by TOF–SIMS
English
Benabdellah, Farida mailto [Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France > > >]
Seyer, Alexandre mailto [Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France > > >]
Quinton, Loïc mailto [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
Touboul, David mailto [Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France > > >]
Brunelle, Alain mailto [Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France > > >]
Laprévote, Olivier mailto [Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France > > >]
Jan-2010
Analytical and Bioanalytical Chemistry
Springer Science & Business Media B.V.
396
1
151-162
Yes (verified by ORBi)
International
1618-2642
1618-2650
Berlin
Germany
[en] Mass spectrometry imaging ; MALDI ; TOF-SIMS ; Lipids ; rat brain
[en] Mass spectrometry imaging is becoming a more
and more widely used method for chemical mapping of
organic and inorganic compounds from various surfaces,
especially tissue sections. Two main different techniques are
now available: matrix-assisted laser desorption/ionizaton,
where the sample, preliminary coated by an organic matrix,
is analyzed by a UV laser beam; and secondary ion mass
spectrometry, for which the target is directly submitted to a
focused ion beam. Both techniques revealed excellent
performances for lipid mapping of tissue surfaces. This
article will discuss similarities, differences, and specificities
of ion images generated by these two techniques in terms of
sample preparation, sensitivity, ultimate spatial resolution,
and structural analysis.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/36811
10.1007/s00216-009-3031-2
http://www.springerlink.com/content/94057kgg46rn6276/

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