ORBi: Benabdellah Farida - Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus nanometer resolution by TOF

Reference : Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus...


	Document type :	Scientific journals : Article
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/36811

Title :	Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus nanometer resolution by TOF–SIMS
Language :	English
Author, co-author :	Benabdellah, Farida [Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France > > >]
	Seyer, Alexandre [Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France > > >]
	Quinton, Loïc [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
	Touboul, David [Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France > > >]
	Brunelle, Alain [Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France > > >]
	Laprévote, Olivier [Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France > > >]
Publication date :	Jan-2010
Journal title :	Analytical and Bioanalytical Chemistry
Publisher :	Springer Science & Business Media B.V.
Volume :	396
Issue/season :	1
Pages :	151-162
Audience :	International
ISSN :	1618-2642
e-ISSN :	1618-2650
City :	Berlin
Country :	Germany
Keywords :	[en] Mass spectrometry imaging ; MALDI ; TOF-SIMS ; Lipids ; rat brain
Abstract :	[en] Mass spectrometry imaging is becoming a more and more widely used method for chemical mapping of organic and inorganic compounds from various surfaces, especially tissue sections. Two main different techniques are now available: matrix-assisted laser desorption/ionizaton, where the sample, preliminary coated by an organic matrix, is analyzed by a UV laser beam; and secondary ion mass spectrometry, for which the target is directly submitted to a focused ion beam. Both techniques revealed excellent performances for lipid mapping of tissue surfaces. This article will discuss similarities, differences, and specificities of ion images generated by these two techniques in terms of sample preparation, sensitivity, ultimate spatial resolution, and structural analysis.
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/36811
DOI :	10.1007/s00216-009-3031-2
Other URL :	http://www.springerlink.com/content/94057kgg46rn6276/

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