Reference : 2,7-dihydroxyapogeissoschizine from root bark of Strychnos gossweileri
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/36776
2,7-dihydroxyapogeissoschizine from root bark of Strychnos gossweileri
English
Quetin-Leclercq, Joëlle [ > > ]
Dive, Georges mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Delaude, Clément [ > > ]
Warin, Roger [ > > ]
Bassleer, Roger [ > > ]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
1994
Phytochemistry
Pergamon Press
35
2
533-536
Yes (verified by ORBi)
International
0031-9422
New York
NY
[en] Strychnos gossweileri ; indole alkaloid ; 2,7-dihydroxyapogeissoschizine ; 2D NMR spectra ; cytotoxic activity ; conformational study
[en] In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based mainly on 1D and 2D NMR studies; its conformation was optimized by energy minimization. This type of skeleton is related to geissoschizine but with the notable diffrence that the 1 and 17 positions are joined giving an additional fused ring. Such a seven-membered ring has ,to our knowledge, only been observed in apogeissoschizine, obtained after chemical tratment of two alkaloids ( geissospermine and geissoschizine). 2,7-dihydroxyapogeissoschizine is therefore, the first natural product possessing this skeleton. According to a preliminary test, this new alkaloid shows low toxicity to B16 melanoma cells, but not for non-cancer 3T3 fibroblasts cultured in vitro.THese results have to be confirmed by further tests.
http://hdl.handle.net/2268/36776

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