Reference : Détermination de la Structure Cristalline et de la Configuration Absolue du Bromhydra...
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Détermination de la Structure Cristalline et de la Configuration Absolue du Bromhydrate d'Usambarensine
[en] Crystal Structure and Absolute Configuration of Usambarensine Hydrobromide
Dideberg, Otto [ > > ]
Dupont, Léon [ > > ]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Acta Crystallographica. Section B-Structural Crystallography and Crystal Chemistry
Munksgaard International Publishers
Yes (verified by ORBi)
[en] Usambarensine Hydrobromide ; Strychnos usambarensis ; X-Ray diffraction ; Absolute configuration
[en] Usambarensine is a bisindolinic alkaloid found in the bark of Strychnos usambarensis roots. The crystal and molecular structure of usambarensine.2HBr.2H2O has been solved by direct methods thanks to a Hilger-Watts four-circle diffractometer. The crystals are monoclinic; refinement of the parameters was carried out with 2459 reflexions. The absolute configuration of the molecule, determined by X-ray anomalous scattering, confirms the 3 alpha cis configuration ( 11alpha cis, IUPAC) assigned earlier by spectral, chromatographic and biogenetic data.This configuration seems dependent on the presence of an ethylidenic chain in the corynane part of the molecule.

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