Reference : Rapid intrapartum test (Strep B OIA) and prenatal cultures for identification of group B...
Scientific congresses and symposiums : Paper published in a book
Human health sciences : Laboratory medicine & medical technology
Human health sciences : Immunology & infectious disease
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
http://hdl.handle.net/2268/36477
Rapid intrapartum test (Strep B OIA) and prenatal cultures for identification of group B streptococcal carriers at delivery: a prospective study
English
MELIN, Pierrette mailto [Centre Hospitalier Universitaire de Liège - CHU > > Microbiologie médicale >]
Schmitz, Myriam [ > > ]
Tsobo, Chantal [ > > ]
HAYETTE, Marie-Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Microbiologie médicale >]
De Mol, Patrick mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale >]
Sep-2000
Program and Abstracts of the 40th Intersciences Conference on Antimicrobial Agents and Chemotherapy
AAmerican Society of Microbiology
American Society for Microbiology (ASM)
Abstract 357 session 30
Yes
No
International
Washington
USA
40th Intersciences Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
du 17 au 20 septembre 2000
American Society of Microbiology
Toronto
Canada
[en] Group B streptococci ; rapid screening ; Strep B OIA ; prenatal cultures ; predictive values
[en] Background: The efficacy of the prenatal screening-based approach recommended by the CDC to prevent neonatal GBS diseases could be improved by using a good rapid test performed at the onset of labor. To assess the Strep B OIA® test (Biostar, Boulder, Co), completed in 30 minutes, we initiated a 6-center study to compare it with prenatal screening cultures to identify GBS carriers at delivery or opportunities to initiate intrapartum antibioprophylaxis (IAP). Methods: For a total of 539 pregnant women included in the study, pairs of vaginal/anal specimens collected at 35-37 weeks and intrapartum vaginal specimens were plated onto colistin-nalidixic agar and then inoculated into selective LIM broth for the detection of GBS. Furthermore, on each intrapartum vaginal swab a Strep B OIA test was performed. Results: GBS were recovered in culture from 89 prenatal screenings (17%) and from 71 specimens collected at delivery (13%). Strep B OIA test identified 48 positive specimens (9%). Respectively, for the identification of GBS carriers at delivery, sensitivity, specificity, positive and negative predictive values for prenatal screening cultures were 69%, 91%, 55% and 95% and for Strep B OIA tests they were 63%, 99%, 94% and 95%. Evaluating opportunities to start an IAP, based on Strep OIA test versus prenatal screening cultures, 45 IAP vs. 49 would have been useful, 3 vs. 40 useless (P< 0,001) and 26 vs. 22 missed. Conclusion: To identify GBS carriers, the Strep B OIA test, performed at the time of onset of labor is equally sensitive to prenatal screening cultures and would allow a highly significant reduction of useless IAP.
Researchers ; Professionals
http://hdl.handle.net/2268/36477

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