ORBi: MELIN Pierrette - Rapid intrapartum test (Strep B OIA) and prenatal cultures for identification of group B streptococcal carriers at delivery: a prospective study

Reference : Rapid intrapartum test (Strep B OIA) and prenatal cultures for identification of group B...


	Document type :	Scientific congresses and symposiums : Paper published in a book
	Discipline(s) :	Human health sciences : Laboratory medicine & medical technology Human health sciences : Immunology & infectious disease Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
	To cite this reference:	http://hdl.handle.net/2268/36477

Title :	Rapid intrapartum test (Strep B OIA) and prenatal cultures for identification of group B streptococcal carriers at delivery: a prospective study
Language :	English
Author, co-author :	MELIN, Pierrette [Centre Hospitalier Universitaire de Liège - CHU > > Microbiologie médicale >]
	Schmitz, Myriam [ > > ]
	Tsobo, Chantal [ > > ]
	HAYETTE, Marie-Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Microbiologie médicale >]
	De Mol, Patrick [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale >]
Publication date :	Sep-2000
Main document title :	Program and Abstracts of the 40th Intersciences Conference on Antimicrobial Agents and Chemotherapy
Editor :	AAmerican Society of Microbiology
Publisher :	American Society for Microbiology (ASM)
Pages :	Abstract 357 session 30
Peer reviewed :	Yes
On invitation :	No
Audience :	International
City :	Washington
Country :	USA
Event name :	40th Intersciences Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
Event date :	du 17 au 20 septembre 2000
Event organizer :	American Society of Microbiology
Event place (city) :	Toronto
Event country :	Canada
Keywords :	[en] Group B streptococci ; rapid screening ; Strep B OIA ; prenatal cultures ; predictive values
Abstract :	[en] Background: The efficacy of the prenatal screening-based approach recommended by the CDC to prevent neonatal GBS diseases could be improved by using a good rapid test performed at the onset of labor. To assess the Strep B OIA® test (Biostar, Boulder, Co), completed in 30 minutes, we initiated a 6-center study to compare it with prenatal screening cultures to identify GBS carriers at delivery or opportunities to initiate intrapartum antibioprophylaxis (IAP). Methods: For a total of 539 pregnant women included in the study, pairs of vaginal/anal specimens collected at 35-37 weeks and intrapartum vaginal specimens were plated onto colistin-nalidixic agar and then inoculated into selective LIM broth for the detection of GBS. Furthermore, on each intrapartum vaginal swab a Strep B OIA test was performed. Results: GBS were recovered in culture from 89 prenatal screenings (17%) and from 71 specimens collected at delivery (13%). Strep B OIA test identified 48 positive specimens (9%). Respectively, for the identification of GBS carriers at delivery, sensitivity, specificity, positive and negative predictive values for prenatal screening cultures were 69%, 91%, 55% and 95% and for Strep B OIA tests they were 63%, 99%, 94% and 95%. Evaluating opportunities to start an IAP, based on Strep OIA test versus prenatal screening cultures, 45 IAP vs. 49 would have been useful, 3 vs. 40 useless (P< 0,001) and 26 vs. 22 missed. Conclusion: To identify GBS carriers, the Strep B OIA test, performed at the time of onset of labor is equally sensitive to prenatal screening cultures and would allow a highly significant reduction of useless IAP.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/36477

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	File	Commentary	Version	Size	Access
Open access	ICAAC2000_GBS OIA.pdf		Publisher postprint	4.13 MB	View/Open

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