Article (Scientific journals)
Effect of naloxone and metoclopropamide on LH secretion in a hyperprolactinemic, hypogonadotropic, postmenopausal woman, fertility and sterility.
Verhelst, J.; Beckers, Albert; Abs, R.
1995In Fertility and Sterility, 64 (5), p. 969-971
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Keywords :
Female; Postmenopause; LH; Gonadotropin RH; Endocrine secretion; Hypogonadism; Chemotherapy; Antagonist; Opiate receptor; Dopamine antagonist; Hyperprolactinemia; Morphinan derivatives; Opioid peptide; Dopaminergic pathway; Peptidergic pathway; Case study; Human; Treatment; Mechanism of action; Gonadotropin; Adenohypophyseal hormone; Hormone releasing factor; Hypothalamic hormone; Endocrinopathy; Femelle; Postménopause; Gonadotrophine RH; Sécrétion endocrine; Hypogonadisme; Chimiothérapie; Naloxone; Antagoniste; Récepteur opiacé; Métoclopramide; Antagoniste dopamine; Hyperprolactinémie; Morphinane dérivé; Peptide opioïde; Voie dopaminergique; Voie peptidergique; Etude cas; Homme; Traitement; Mécanisme action; Benzamide dérivé; Gonadotrophine; Hormone adénohypophysaire; Facteur libération hormonale; Hormone hypothalamique; Endocrinopathie
Abstract :
[en] OBJECTIVE: To determine the role of opioidergic and dopaminergic activity in the suppression of GnRH0LH in a hyperprolactinemic state. DESIGN: Case report. SETTING: University hospital. PATIENT: A 68-year-old woman with a macroprolactinoma. INTERVENTIONS: Serial 10-hour IV infusions of naloxone and metoclopramide. MAIN OUTCOME MEASURE: Serum LH concentration. RESULTS: Naloxone induced a small but significant rise of serum LH levels, which displayed a pulsatile pattern. By contrast, metoclopramide elicited no significant response in LH secretion. CONCLUSION: Opioidergic but not dopaminergic neurotransmission plays a direct role in the suppression of LH secondary to hyperprolactinemia.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Verhelst, J.
Beckers, Albert ;  Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie
Abs, R.
Language :
English
Title :
Effect of naloxone and metoclopropamide on LH secretion in a hyperprolactinemic, hypogonadotropic, postmenopausal woman, fertility and sterility.
Publication date :
November 1995
Journal title :
Fertility and Sterility
ISSN :
0015-0282
eISSN :
1556-5653
Publisher :
Elsevier, New York, United States - New York
Volume :
64
Issue :
5
Pages :
969-971
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 May 2010

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