Reference : Familial Acromegaly: Case Report and Review of the Literature
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Familial Acromegaly: Case Report and Review of the Literature
Verloes, Alain [Université de Liège - ULg > > Génétique >]
Stevenaert, Achille [Université de Liège - ULg > > Neurochirurgie >]
Teh, B. T. [ > > ]
Petrossians, Patrick [Université de Liège - ULg > > Endocrinologie clinique >]
Beckers, Albert mailto [Université de Liège - ULg > Département des sciences cliniques > Endocrinologie >]
Springer Netherlands
Yes (verified by ORBi)
[en] acromegaly ; familial acromegaly ; chromophobe tumor ; MEN1
[en] Familial acromegaly is an exceptional clinical entity when not associated with features of multiple endocrine neoplasia type 1 (MEN1). We report here 3 pedigrees in each of which 2 patients have been shown to develop acromegaly. In 4 patients, clinical follow-up, and biological screening allowed to confidently exclude MEN1. Absence of mutation in the MEN1 gene after direct DNA analysis in 2 pedigrees reinforces the conviction that the families do not have MEN1. In families 1 and 2, diagnosis was made at a very early age and voluminous adenomas with suprasellar expansion were already present at the time of diagnosis. We review the 20 previous reports of familial acromegaly, some of them questionable. Our 3 families, combined with some other published pedigrees, allow the delineation of a familial form of acromegaly, distinct from MEN1. Dominant inheritance with reduced, age-dependant penetrance is the most parsimonious model to explain the recurrences. Gs protein pathway could be the site of action of the gene responsible of familial acromegaly, but no data have been published to sustain or reject this hypothesis.
Researchers ; Professionals

File(s) associated to this reference

Fulltext file(s):

Restricted access
Familial Acromegaly - Case Report and Review of the Literature.pdfPublisher postprint79.91 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.