Reference : Evidence for Free Radical Formation During Human Kidney Transplantation
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
http://hdl.handle.net/2268/36258
Evidence for Free Radical Formation During Human Kidney Transplantation
English
Pincemail, Joël mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
Defraigne, Jean-Olivier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie générale]
Franssen, Christine mailto [Université de Liège - ULg > Département de sciences des denrées alimentaires > Microbiologie des denrées alimentaires >]
Bonnet, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Urologie >]
Deby-Dupont, G. [université de liège > > > > > >]
Pirenne, J. [Katholieke Universiteit Leuven - KUL > > > > > >]
deby [centre de l'oxygène CHU Ulg > > > >]
Lamy, Maurice mailto [Université de Liège - ULg > Département des sciences cliniques > Anesthésie et réanimation]
Limet, Raymond mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Meurisse, Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Chirurgicale abdominale]
Sep-1993
Free Radical Biology & Medicine
15
3
343-8
No
International
0891-5849
[en] Fourteen patients undergoing kidney transplantation were studied for evidence of the production of free radicals as assessed by the measurement of vitamin E (an index of lipid peroxidation) and of myeloperoxidase (a marker of neutrophil activation) in the systemic blood. Early (2 min) and late revascularization (30 min) of the kidney were respectively associated with a significant decrease of 35.5 and 40% of the initial level of plasma vitamin E. This consumption paralleled to the decrease of the vitamin E/total lipids ratio, a better indicator of vitamin E status. Heparin administration preceding renal artery clamping resulted in a twofold significant increase of baseline plasma myeloperoxidase (MPO) level (523 +/- 214 ng/ml). At kidney reperfusion, MPO concentration rose again and reached a maximum value of 1,653 +/- 882 ng/ml, indicating the presence of considerable neutrophil activation. A return to the baseline value was observed after 30 min of reperfusion. A short discussion about the possible origin of this MPO increase is given. Taken together, these data strongly suggest that free radical production, leading to lipid peroxidation phenomena, can occur within the early phase of kidney revascularization. Preliminary data using electron spin resonance with the spin-trapping technique strengthen this hypothesis.
http://hdl.handle.net/2268/36258

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