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Evidence for Free Radical Formation During Human Kidney Transplantation
Pincemail, Joël; Defraigne, Jean-Olivier; Franssen, Christine et al.
1993In Free Radical Biology and Medicine, 15 (3), p. 343-8
 

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Abstract :
[en] Fourteen patients undergoing kidney transplantation were studied for evidence of the production of free radicals as assessed by the measurement of vitamin E (an index of lipid peroxidation) and of myeloperoxidase (a marker of neutrophil activation) in the systemic blood. Early (2 min) and late revascularization (30 min) of the kidney were respectively associated with a significant decrease of 35.5 and 40% of the initial level of plasma vitamin E. This consumption paralleled to the decrease of the vitamin E/total lipids ratio, a better indicator of vitamin E status. Heparin administration preceding renal artery clamping resulted in a twofold significant increase of baseline plasma myeloperoxidase (MPO) level (523 +/- 214 ng/ml). At kidney reperfusion, MPO concentration rose again and reached a maximum value of 1,653 +/- 882 ng/ml, indicating the presence of considerable neutrophil activation. A return to the baseline value was observed after 30 min of reperfusion. A short discussion about the possible origin of this MPO increase is given. Taken together, these data strongly suggest that free radical production, leading to lipid peroxidation phenomena, can occur within the early phase of kidney revascularization. Preliminary data using electron spin resonance with the spin-trapping technique strengthen this hypothesis.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Pincemail, Joël ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire
Defraigne, Jean-Olivier ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie générale
Franssen, Christine ;  Université de Liège - ULiège > Département de sciences des denrées alimentaires > Microbiologie des denrées alimentaires
Bonnet, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Urologie
Dupont, Ginette ;  Université de Liège - ULiège > Centres généraux > Centre de l'oxygène : Recherche et développement (C.O.R.D.)
Pirenne, J.;  Katholieke Universiteit Leuven - KUL
Deby, Carol ;  Université de Liège - ULiège > centre de l'oxygène CHU
Lamy, Maurice ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Limet, Raymond ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Meurisse, Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Chirurgicale abdominale
Language :
English
Title :
Evidence for Free Radical Formation During Human Kidney Transplantation
Publication date :
September 1993
Journal title :
Free Radical Biology and Medicine
ISSN :
0891-5849
eISSN :
1873-4596
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
15
Issue :
3
Pages :
343-8
Available on ORBi :
since 16 May 2010

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