Reference : Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in canc...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/36155
Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease.
English
Van de Veire, Sara [> > > >]
Stalmans, Ingeborg [> > > >]
Heindryckx, Femke [> > > >]
Oura, Hajimu [> > > >]
Tijeras-Raballand, Annemilai [> > > >]
Schmidt, Thomas [> > > >]
Loges, Sonja [> > > >]
Albrecht, Imke [> > > >]
Jonckx, Bart [> > > >]
Vinckier, Stefan [> > > >]
Van Steenkiste, Christophe [> > > >]
Tugues, Sonia [> > > >]
Rolny, Charlotte [> > > >]
De Mol, Maria [> > > >]
Dettori, Daniela [> > > >]
Hainaud, Patricia [> > > >]
Coenegrachts, Lieve [> > > >]
Contreres, Jean*-Olivier [> > > >]
Van Bergen, Tine [> > > >]
Cuervo, Henar [> > > >]
Xiao, Wei*-Hong [> > > >]
Le Henaff, Carole [> > > >]
Buysschaert, Ian [> > > >]
Kharabi Masouleh, Behzad [> > > >]
Geerts, Anja [> > > >]
Schomber, Tibor [> > > >]
Bonnin, Philippe [> > > >]
Lambert, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Ophtalmologie >]
Haustraete, Jurgen [> > > >]
Zacchigna, Serena [> > > >]
Rakic, Jean-Marie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Ophtalmologie >]
Jimenez, Wladimiro [> > > >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Giacca, Mauro [> > > >]
Colle, Isabelle [> > > >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
Tobelem, Gerard [> > > >]
Morales-Ruiz, Manuel [> > > >]
Vilar, Jose [> > > >]
Maxwell, Patrick [> > > >]
Vinores, Stanley A [> > > >]
Carmeliet, Geert [> > > >]
Dewerchin, Mieke [> > > >]
Claesson-Welsh, Lena [> > > >]
Dupuy, Evelyne [> > > >]
Van Vlierberghe, Hans [> > > >]
Christofori, Gerhard [> > > >]
Mazzone, Massimiliano [> > > >]
Detmar, Michael [> > > >]
Collen, Desire [> > > >]
Carmeliet, Peter [> > > >]
2010
Cell
Cell Press
141
1
178-90
Yes (verified by ORBi)
International
0092-8674
1097-4172
Cambridge
MA
[en] PlGF ; tumor models ; eye disease ; ocular neovascluarization ; anticancer therapies
[en] Our findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al. Here we take advantage of carcinogen-induced and transgenic tumor models as well as ocular neovascularization to report further evidence in support of our original findings of PlGF as a promising target for anticancer therapies. We present evidence for the efficacy of additional anti-PlGF antibodies and their ability to phenocopy genetic deficiency or silencing of PlGF in cancer and ocular disease but also show that not all anti-PlGF antibodies are effective. We also provide additional evidence for the specificity of our anti-PlGF antibody and experiments to suggest that anti-PlGF treatment will not be effective for all tumors and why. Further, we show that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease. Our findings warrant further testing of anti-PlGF therapies.
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/2268/36155
10.1016/j.cell.2010.02.039
Copyright 2010 Elsevier Inc. All rights reserved.

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