Reference : Tgf-beta1 Modulates bFGF Receptor Message Expression in Cultured Adult Auditory Neurons

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Anatomy (cytology, histology, embryology...) & physiology Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/36088

Title :	Tgf-beta1 Modulates bFGF Receptor Message Expression in Cultured Adult Auditory Neurons
Language :	English
Author, co-author :	Lefebvre, P. P. [> > > >]
	Staecker, H. [> > > >]
	Weber, T. [> > > >]
	Van de Water, T. R. [> > > >]
	Rogister, Bernard [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
	Moonen, Gustave [Université de Liège - ULg > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine]
Publication date :	Jun-1991
Journal title :	Neuroreport
Volume :	2
Issue/season :	6
Pages :	305-8
Audience :	International
ISSN :	0959-4965
Abstract :	[en] Basic fibroblast growth factor (bFGF) has been shown to have neuronotrophic effects on cultured neurons. Transforming growth factor beta (TGFss1) has been implicated in the modulation of cellular receptors for bFGF in several cell types. In this study, we show that TGFss1 is expressed in cultured adult mouse auditory neurons in response to explanation injury and acts in an autocrine fashion to increase the level of expression of bFGF receptors message in these same neurons. Based on these in-vitro results, we propose that these trophic factors (i.e. TGFss1 and bFGF) play a significant role in the response to injury by the mature auditory system.
Permalink :	http://hdl.handle.net/2268/36088

There is no file associated with this reference.

All documents in ORBi are protected by a user license.

 

© ULg Library Network |  Feedback |  ORBi legal notices

Dspace v1.5