Reference : Tgf-beta1 Modulates bFGF Receptor Message Expression in Cultured Adult Auditory Neurons
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/36088
Tgf-beta1 Modulates bFGF Receptor Message Expression in Cultured Adult Auditory Neurons
English
Lefebvre, P. P. [> > > >]
Staecker, H. [> > > >]
Weber, T. [> > > >]
Van de Water, T. R. [> > > >]
Rogister, Bernard mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Moonen, Gustave mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine]
Jun-1991
Neuroreport
2
6
305-8
Yes (verified by ORBi)
International
0959-4965
[en] Basic fibroblast growth factor (bFGF) has been shown to have neuronotrophic effects on cultured neurons. Transforming growth factor beta (TGFss1) has been implicated in the modulation of cellular receptors for bFGF in several cell types. In this study, we show that TGFss1 is expressed in cultured adult mouse auditory neurons in response to explanation injury and acts in an autocrine fashion to increase the level of expression of bFGF receptors message in these same neurons. Based on these in-vitro results, we propose that these trophic factors (i.e. TGFss1 and bFGF) play a significant role in the response to injury by the mature auditory system.
http://hdl.handle.net/2268/36088

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