Article (Scientific journals)
The importance of liposomes as models and tools in the understanding of photosensitization mechanisms
Hoebeke, Maryse
1995In Journal of Photochemistry and Photobiology B: Biology, 28 (3), p. 189-196
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Keywords :
Liposomes; Photosensitization; Photodynamic therapy
Abstract :
[en] The various applications of liposomes in understanding photosensitization are described in this paper, with particular emphasis on the various kinds of information that these models allow to obtain in phototherapy. Liposomes are simple vesicles in which an aqueous phase is enclosed by a phospholipidic membrane. They are suitable models mimicking specific situations occurring <br />m vivo and they allow study of the influence of physieochemieal, photobioiogieal and biochemical factors on the uptake of photosensitizers by tissues, their mechanisms of action and the subsequent photoinduced tumor necrosis. Moreover, solubilization of the sensitizer into the bilayer seems to improve its tumoral selectivity and its photodynamic efficiency.
Disciplines :
Physics
Author, co-author :
Hoebeke, Maryse  ;  Université de Liège - ULiège > Département de physique > Spectroscopie biomédicale
Language :
English
Title :
The importance of liposomes as models and tools in the understanding of photosensitization mechanisms
Publication date :
1995
Journal title :
Journal of Photochemistry and Photobiology B: Biology
ISSN :
1011-1344
Publisher :
Elsevier Science, Lausanne, Switzerland
Volume :
28
Issue :
3
Pages :
189-196
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 May 2010

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