Reference : Varicella-zoster virus induces apoptosis in cell culture
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/3560
Varicella-zoster virus induces apoptosis in cell culture
English
Sadzot-Delvaux, Catherine mailto [Université de Liège > Département des sciences de la vie > Virologie et immunologie > >]
Thonard, P. [Université de Liège - ULg > Sciences de la Vie > Virologie fondamentale et Immunologie > >]
Schoonbroodt, Sonia [Université de Liège - ULg > Sciences de la Vie > Virologie fondamentale et Immunologie > >]
Piette, Jacques mailto [Université de Liège - ULg > Département des sciences de la vie > Virologie - Immunologie >]
Rentier, Bernard mailto [Université de Liège - ULg > Département de Microbiologie > Virologie fondamentale et Immunologie > >]
1995
Journal of General Virology (The)
Society for General microbiology
76
Pt 11
2875-2879
Yes (verified by ORBi)
International
0022-1317
[en] Varicella-zoster virus ; apoptosis
[en] Apoptosis is an active mechanism of cell death which can be initiated in response to various stimuli including virus infections. In this work, we demonstrate that lytic infection by varicella-zoster virus (VZV), a human herpesvirus, is characterized by nuclear fragmentation of DNA into oligonucleosomal fragments and by chromatin condensation. In vitro, VZV-induced cell death is actually mediated by apoptosis. The mechanisms developed by cells to protect themselves against apoptosis could be one of the parameters allowing the establishment of virus latency. In the case of VZV, which can remain latent in sensory ganglia, we have not yet identified a cellular or viral protein which could play this protective role, since the observed apoptosis mechanism seems to be independent from Bcl-2, the most frequently described inhibitor of apoptosis.
Researchers
http://hdl.handle.net/2268/3560

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