Reference : Expression of members of the putative olfactory receptor gene family in mammalian ger...
Scientific journals : Article
Life sciences : Genetics & genetic processes
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/35338
Expression of members of the putative olfactory receptor gene family in mammalian germ cells.
English
Parmentier, M. [Université Libre de Bruxelles - ULB > IRIBHN > > >]
Libert, F. [Université Libre de Bruxelles - ULB > IRIBHN > > >]
Schurmans, Stéphane mailto [Université Libre de Bruxelles - ULB > Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Institut de Biologie et de Médecine Moléculaire > > >]
Schiffmann, S. [Université Libre de Bruxelles - ULB > > > >]
Lefort, A. [Université Libre de Bruxelles - ULB > IRIBHN > > >]
Eggerickx, D. [Université Libre de Bruxelles - ULB > IRIBHN > > >]
Ledent, C. [Université Libre de Bruxelles - ULB > > > >]
Mollereau, C. [Laboratoire de Pharmacologie et de Toxicologie fondamentale du CNRS Toulouse France > > > >]
Gerard, C. [Université Libre de Bruxelles - ULB > IRIBHN > > >]
Perret, J. [Université Libre de Bruxelles - ULB > IRIBHN > > >]
Grootegoed, A. [Erasmus Universiteit Rotterdam - EUR > Medical faculty > > >]
Vassart, G. [Université Libre de Bruxelles - ULB > IRIBHN > > >]
1992
Nature
Nature Publishing Group
355
453-455
Yes (verified by ORBi)
International
0028-0836
1476-4687
Basingstoke
United Kingdom
[en] A series of genomic and complementary DNA clones encoding new putative members of G protein-coupled receptors were isolated using homology cloning and low-stringency polymerase chain reaction. Among the unidentified receptors ('orphan receptors'), a human genomic clone (HGMP07) was characterized by the presence of its transcripts in the testis and by its belonging to a large subfamily of genes sharing extensive sequence similarities. Sequence comparison demonstrated that this gene subfamily is the human counterpart of the putative rat olfactory receptors cloned recently. Another 48 members of the family were cloned. Northern blotting further demonstrated the presence of olfactory receptor transcripts in germ cells. Our finding suggests that a common receptor gene family encodes olfactory receptors and sperm cell receptors that could be involved in chemotaxis during fertilization
Researchers ; Professionals
http://hdl.handle.net/2268/35338
10.1038/355453a0

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