Reference : Modulation of the Clozapine Structure Increases Its Selectivity for the Dopamine D4 R...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/35314
Modulation of the Clozapine Structure Increases Its Selectivity for the Dopamine D4 Receptor
English
Liégeois, Jean-François mailto [Université de Liège - ULg > Département de pharmacie > Chimie pharmaceutique >]
Bruhwyler, J. [> > > >]
Damas, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Rogister, F. [> > > >]
Masereel, B. [> > > >]
Geczy, J. [> > > >]
Delarge, J. [> > > >]
1995
European Journal of Pharmacology
273
3
R1-3
Yes (verified by ORBi)
International
0014-2999
[en] Clozapine has a more marked affinity for the recently cloned dopamine D4 receptor than for the dopamine D2 receptor. In the search for a selective ligand for the dopamine D4 receptor, useful as a pharmacological tool or as a potent atypical antipsychotic, a pyridobenzodiazepine derivative bioisoster of clozapine, JL 18, 8-methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido [2,3-b][1,4]benzodiazepine, was found to be the most dopamine D4-selective ligand belonging to the diarylazepine class. Indeed, JL 18 binds to the dopamine D4 receptor with affinity up to 25 times superior to that for the dopamine D2 receptor and presents reduced affinities for other receptors.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/35314

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