|Reference : Peroxidase-Catalysed Oxidation of Different Dibenzazepine Derivatives|
|Scientific journals : Article|
|Human health sciences : Pharmacy, pharmacology & toxicology|
|Peroxidase-Catalysed Oxidation of Different Dibenzazepine Derivatives|
|Liégeois, Jean-François [Université de Liège - ULg > Département de pharmacie > Chimie pharmaceutique >]|
|Rogister, F. [> > > >]|
|Delarge, J. [> > > >]|
|Pincemail, Joël [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]|
|Archiv der Pharmazie|
|Yes (verified by ORBi)|
|[en] According to a recent hypothesis suggesting the potential role of free radical formation in the clozapine-induced agranulocytosis, we have evaluated the susceptibility to the peroxidase-mediated oxidation of different dibenzazepine analogues. On the one hand, compounds with an arylamine group such as clozapine or isoclozapine present a high reactivity in the horseradish peroxidase or myeloperoxidase systems and, on the other hand, fluperlapine, though known to induce agranulocytosis, and other dibenzothiazepine and dibenzoxazepine derivatives appear insensitive to oxidation. Consequently, among tricyclic derivatives, the way of diaryloxa- and diarylthiazepine compounds could be an alternative for the development of safer drugs such as antipsychotics.|
|Researchers ; Professionals ; Students|
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