Reference : Peroxidase-Catalysed Oxidation of Different Dibenzazepine Derivatives
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/35312
Peroxidase-Catalysed Oxidation of Different Dibenzazepine Derivatives
English
Liégeois, Jean-François mailto [Université de Liège - ULg > Département de pharmacie > Chimie pharmaceutique >]
Rogister, F. [> > > >]
Delarge, J. [> > > >]
Pincemail, Joël mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
Feb-1995
Archiv der Pharmazie
328
2
109-12
Yes (verified by ORBi)
International
0365-6233
[en] According to a recent hypothesis suggesting the potential role of free radical formation in the clozapine-induced agranulocytosis, we have evaluated the susceptibility to the peroxidase-mediated oxidation of different dibenzazepine analogues. On the one hand, compounds with an arylamine group such as clozapine or isoclozapine present a high reactivity in the horseradish peroxidase or myeloperoxidase systems and, on the other hand, fluperlapine, though known to induce agranulocytosis, and other dibenzothiazepine and dibenzoxazepine derivatives appear insensitive to oxidation. Consequently, among tricyclic derivatives, the way of diaryloxa- and diarylthiazepine compounds could be an alternative for the development of safer drugs such as antipsychotics.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/35312

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