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| Reference : Autoimmune syndrome after neonatal induction of tolerance to alloantigens: analysis of t... |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology Life sciences : Genetics & genetic processes | |||
| http://hdl.handle.net/2268/35308 | |||
| Autoimmune syndrome after neonatal induction of tolerance to alloantigens: analysis of the specificity and of the cellular and genetic origin of autoantibodies | |
| English | |
Schurmans, Stéphane  [Université Libre de Bruxelles - ULB > Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Institut de Biologie et de Médecine Moléculaire > > >] | |
| Merino, J. [WHO Immunology Research und Training Center > > > >] | |
| Qin, H. [WHO Immunology Research und Training Center > > > >] | |
| Kramar, G. [WHO Immunology Research und Training Center > > > >] | |
| Duchosal, M. [Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CaliforniaUSA > > > >] | |
| Skalli, O. [Department of Pathology, CMU, 1 rue Michel-Servet, 1211, Geneva, Switzerland > > > >] | |
| Benzonana, G. [Department of Pathology, CMU, 1 rue Michel-Servet, 1211, Geneva, Switzerland > > > >] | |
| Gabbiani, G. [Department of Pathology, CMU, 1 rue Michel-Servet, 1211, Geneva, Switzerland > > > >] | |
| Lambert, P. H. [WHO Immunology Research und Training Center > > > >] | |
| 1991 | |
| Autoimmunity | |
| Taylor & Francis | |
| 9 | |
| 283-291 | |
| Yes (verified by ORBi) | |
| International | |
| 0891-6934 | |
| 1607-842X | |
| London | |
| United Kingdom | |
| [en] Autoimmune ; syndrome ; neonatal induction ; alloantigens ; autoantibodies ; origin | |
| [en] BALB/c mice neonatally injected with 10(8) semiallogeneic (C57BL/6 x BALB/c)F1 spleen cells become tolerant to the H-2b alloantigens, but also develop a wide range of autoimmune manifestations characteristic of systemic lupus erythematosus (SLE). Indeed, in these mice, the presence of a hypergammaglobulinaemia, autoantibodies--including anti-ssDNA, anti-platelet, thymocytotoxic and rheumatoid factor antibodies--circulating immune complexes, cryoglobulins as well as renal glomerular deposition of immunoglobulins have been observed. In this study, we have shown that the allogenic effect and B cell chimaerism which characterize these F1 cell-injected mice is associated with the expression of a large spectrum of autoantibodies, including anti-ssDNA and anti-cytoskeleton antibodies, and that these autoantibodies are not multispecific. We took advantage of the fact that, in this model, autoantibodies are exclusively produced by F1 donor B cells to inject newborn BALB/c mice with F1 Xid spleen cells lacking the CD5+ B cell subset. Injection of 2 x 10(8) F1 Xid spleen cells triggers the production of anti-ssDNA as well as anti-BrMRBC antibodies, and these mice developed tissue lesions. Finally, analysis of the VH gene family expressed by monoclonal autoantibodies derived from F1 cell-injected mice showed that they used the 2 largest families J558 and 7183. These results suggest that the allogenic effect and B cell chimerism which characterize the neonatal induction of tolerance to MHC alloantigens is associated with the selective triggering of autoreactive B cells producing monospecific IgG autoantibodies. They also imply that upon stimulation by persisting alloreactive CD4+ T cells, either CD5- B cells are able to produce autoantibodies or autoantibody-producing CD5+ B cells can differentiate from Xid spleen cells | |
| Researchers ; Professionals | |
| http://hdl.handle.net/2268/35308 |
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