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Anxiolytic potential of sulpiride, clozapine and derivatives in the open-field test.
Bruhwyler, J.; Chleide, E.; Liégeois, Jean-François et al.
1990In Pharmacology, Biochemistry and Behavior, 36 (1), p. 57-61
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Keywords :
Animals; Chlordiazepoxide/pharmacology; Clozapine/pharmacology; Defecation/drug effects; Dibenzazepines/pharmacology; Exploratory Behavior/drug effects; Haloperidol/pharmacology; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sulpiride/pharmacology
Abstract :
[en] Recently acquired data question the sharp dichotomy between anxiolytics and neuroleptics, since disinhibitory effects have been measured in the rat with very low doses of haloperidol and higher doses of atypical neuroleptics in FI and DRL schedules, but also in the open-field test. That the DA transmission in certain brain regions is involved in some aspects of anxiety has recently been suggested. The present study confirms this hypothesis particularly with high doses of sulpiride (80 mg/kg) and clozapine (24 mg/kg) when tested in the open-field test. Moreover, the results show how a slight chemical modification of clozapine can give a direction to pharmacological activity with one derivative still resembling clozapine and the second one resembling haloperidol. As neuroleptics do not seem to influence the synthesis and utilization of GABA, the higher entry score observed with them would seem to depend above all on DA antagonism in the mesolimbic system.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Bruhwyler, J.
Chleide, E.
Liégeois, Jean-François ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Delarge, J.
Mercier, M.
Language :
English
Title :
Anxiolytic potential of sulpiride, clozapine and derivatives in the open-field test.
Publication date :
1990
Journal title :
Pharmacology, Biochemistry and Behavior
ISSN :
0091-3057
Publisher :
Elsevier, Tarrytown, United States - New York
Volume :
36
Issue :
1
Pages :
57-61
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 January 2010

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