Reference : Protein-protein interactions and gene expression regulation in HTLV-1 infected cells.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/35212
Protein-protein interactions and gene expression regulation in HTLV-1 infected cells.
English
Legros, Sébastien [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Boxus, Mathieu mailto [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Dewulf, Jean Francois [> > > >]
Dequiedt, Franck mailto [Université de Liège - ULg > > GIGA-Research >]
Kettmann, Richard mailto [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Twizere, Jean-Claude mailto [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
2009
Frontiers in Bioscience : A Journal and Virtual Library
Frontiers in Bioscience Publications
14
4138-48
Yes (verified by ORBi)
International
1093-9946
1093-4715
Tampa
FL
[en] Gene Expression Regulation, Viral ; Human T-lymphotropic virus 1/genetics/metabolism ; Humans ; Protein Binding ; Viral Proteins/metabolism
[en] Human T-cell leukemia virus type 1 (HTLV-1) propagates in CD4 or CD8 T cells and, after extended latency periods of 30-50 years, causes a rapidly fatal leukemia called adult T-cell leukemia/lymphoma (ATL). Infection with HTLV-1 is also associated with a degenerative neuromuscular disease referred to as tropical spastic paraparesis or HTLV-1-associated myelopathy. HTLV genome, in addition to the structural proteins and retroviral enzymes, codes for a region at its 3' end originally designated pX. The products of this region (Tax, Rex, p12I, p13II, p30II and HBZ) play important roles in deregulation of cellular functions by either directly disrupting cellular factors or altering transcription of viral and cellular genes. Here, we will review current knowledge of protein-protein interactions that regulate transcriptional functions of proteins encoded by the pX region.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/35212

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Legros et al 2009.pdfPublisher postprint625.89 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.