Article (Scientific journals)
Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling.
Twizere, Jean-Claude; Springael, Jean-Yves; Boxus, Mathieu et al.
2007In Blood, 109 (3), p. 1051-60
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Keywords :
Cells, Cultured; Chemokine CXCL12; Chemokines, CXC/metabolism; Deltaretrovirus Infections; GTP-Binding Proteins/metabolism/physiology; Gene Products, tax/genetics/physiology; Humans; Receptors, CXCR4/metabolism; Receptors, G-Protein-Coupled/physiology; Signal Transduction; T-Lymphocytes; Transduction, Genetic
Abstract :
[en] Human T-cell leukemia virus type-1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and neurological syndromes. HTLV-1 encodes the oncoprotein Tax-1, which modulates viral and cellular gene expression leading to T-cell transformation. Guanine nucleotide-binding proteins (G proteins) and G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins known and are involved in the regulation of most biological functions. Here, we report an interaction between HTLV-1 Tax oncoprotein and the G-protein beta subunit. Interestingly, though the G-protein beta subunit inhibits Tax-mediated viral transcription, Tax-1 perturbs G-protein beta subcellular localization. Functional evidence for these observations was obtained using conditional Tax-1-expressing transformed T-lymphocytes, where Tax expression correlated with activation of the SDF-1/CXCR4 axis. Our data indicated that HTLV-1 developed a strategy based on the activation of the SDF-1/CXCR4 axis in the infected cell; this could have tremendous implications for new therapeutic strategies.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Twizere, Jean-Claude  ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Springael, Jean-Yves
Boxus, Mathieu ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Burny, Arsène ;  Université de Liège - ULiège > Agro Biotech Gembloux
Dequiedt, Franck  ;  Université de Liège - ULiège > GIGA-Research
Dewulf, Jean-Francois
Duchateau, Julie
Portetelle, Daniel ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Urbain, Patrice
Van Lint, Carine
Green, Patrick L
Mahieux, Renaud
Parmentier, Marc
Willems, Luc  ;  Université de Liège - ULiège > GIGA-Research - Gembloux Agro-Bio Tech
Kettmann, Richard ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
More authors (5 more) Less
Language :
English
Title :
Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling.
Publication date :
2007
Journal title :
Blood
ISSN :
0006-4971
eISSN :
1528-0020
Publisher :
American Society of Hematology, Washington, United States - District of Columbia
Volume :
109
Issue :
3
Pages :
1051-60
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 January 2010

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