Reference : Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/35210
Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling.
English
Twizere, Jean-Claude mailto [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Springael, Jean-Yves [> > > >]
Boxus, Mathieu mailto [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Burny, Arsene [> > > >]
Dequiedt, Franck mailto [Université de Liège - ULg > > GIGA-Research >]
Dewulf, Jean-Francois [> > > >]
Duchateau, Julie [> > > >]
Portetelle, Daniel mailto [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Urbain, Patrice [> > > >]
Van Lint, Carine [> > > >]
Green, Patrick L [> > > >]
Mahieux, Renaud [> > > >]
Parmentier, Marc [> > > >]
Willems, Luc mailto [Université de Liège - ULg > > GIGA-Research - Gembloux Agro-Bio Tech >]
Kettmann, Richard mailto [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
2007
Blood
American Society of Hematology
109
3
1051-60
Yes (verified by ORBi)
International
0006-4971
1528-0020
Washington
DC
[en] Cells, Cultured ; Chemokine CXCL12 ; Chemokines, CXC/metabolism ; Deltaretrovirus Infections ; GTP-Binding Proteins/metabolism/physiology ; Gene Products, tax/genetics/physiology ; Humans ; Receptors, CXCR4/metabolism ; Receptors, G-Protein-Coupled/physiology ; Signal Transduction ; T-Lymphocytes ; Transduction, Genetic
[en] Human T-cell leukemia virus type-1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and neurological syndromes. HTLV-1 encodes the oncoprotein Tax-1, which modulates viral and cellular gene expression leading to T-cell transformation. Guanine nucleotide-binding proteins (G proteins) and G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins known and are involved in the regulation of most biological functions. Here, we report an interaction between HTLV-1 Tax oncoprotein and the G-protein beta subunit. Interestingly, though the G-protein beta subunit inhibits Tax-mediated viral transcription, Tax-1 perturbs G-protein beta subcellular localization. Functional evidence for these observations was obtained using conditional Tax-1-expressing transformed T-lymphocytes, where Tax expression correlated with activation of the SDF-1/CXCR4 axis. Our data indicated that HTLV-1 developed a strategy based on the activation of the SDF-1/CXCR4 axis in the infected cell; this could have tremendous implications for new therapeutic strategies.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/35210
also: http://hdl.handle.net/2268/10539
10.1182/blood-2006-06-026781

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