ORBi: Vanderhaeghen P. - Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome

Reference : Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the m...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology Life sciences : Genetics & genetic processes
	To cite this reference:	http://hdl.handle.net/2268/35042

Title :	Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome
Language :	English
Author, co-author :	Vanderhaeghen, P. [Université Libre de Bruxelles - ULB > > > >]
	Schurmans, Stéphane [Université Libre de Bruxelles - ULB > Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Institut de Biologie et de Médecine Moléculaire > > >]
	Vassart, G. [Université Libre de Bruxelles - ULB > > > >]
	Parmentier, M. [Université Libre de Bruxelles - ULB > > > >]
Publication date :	1997
Journal title :	Biochemical and Biophysical Research Communications
Publisher :	Academic Press
Volume :	237
Pages :	283-287
Audience :	International
ISSN :	0006-291X
e-ISSN :	1090-2104
City :	San Diego
Country :	CA
Keywords :	[en] cloning ; chromosomal mapping ; olfactory receptor ; genes ; male germ ; genome ; human
Abstract :	[en] Olfactory receptor genes constitute the largest family of G protein-coupled receptors. We have previously shown that members of this family are expressed during spermatogenesis, and that the corresponding proteins are displayed on mature sperm cells. In each mammalian species, a restricted subset of olfactory receptors is expressed in male germ cells and displays a pattern of expression suggestive of their potential implication in the control of sperm physiology. In addition to the cDNA fragments available previously, we now report the molecular cloning of two olfactory receptor cDNAs from a human testis library. Five olfactory receptor genes expressed in germ cells were localized in the human genome by radiation hybrid mapping. Three of the genes map to the short arm of chromosome 19 (19p13.1-19p31.3), one to chromosome 11 (11q22.1-22.3), and one to chromosome 17 (17q21-22). The former two localizations fall within clusters previously identified for members of the putative olfactory receptor gene family expressed in olfactory mucosa. Similarly, sequence analysis has revealed that these testicular genes share no distinctive structural features from the other, non-testicular, members of the family. The expression of a subset of olfactory receptor genes in the male germ line is therefore not correlated to their belonging to a specific structural subgroup, or to a specific gene cluster or chromosomal segment
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/35042

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