Reference : Resistance of paramyxoviridae to type I interferon-induced Bos taurus Mx1 dynamin
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/35021
Resistance of paramyxoviridae to type I interferon-induced Bos taurus Mx1 dynamin
English
Leroy, Michael [Université de Liège - ULG > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies > >]
Baise, Etienne mailto [Université de Liège - ULg > Département des sciences de la vie > Macromolécules biologiques >]
Pire, Grégory [Université de Liège - ULG > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies > >]
Gérardin, Joël mailto [Université de Liège - ULg > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies > >]
Desmecht, Daniel mailto [Université de Liège - ULg > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies > >]
2005
Journal of Interferon & Cytokine Research
Mary Ann Liebert Inc
25
4
192-201
Yes (verified by ORBi)
International
1079-9907
New Rochelle
NY
[en] paramyxoviridae ; interferon ; Mx
[en] Typical targets of type I interferon (IFN)-induced antiviral Mx proteins known to date have been shown to share a common profile: single-stranded negative-sense RNA viruses. Among them, human MxA is known to interfere with the replication of measles, human, and bovine parainfluenza-3 viruses (BoPi3V), that is, three members of the Paramyxoviridae family. Recently, bovine Mx1 protein (BoMx1) was included in the group of Mx proteins with authenticated antiviral potential, as it dramatically represses the replication of vesicular stomatitis virus (VSV). As replication in bovine cells of Pi3, respiratory syncytial (RS), and Sendai (Se) viruses, all members of the same family, is known to be reduced on IFN-alpha incorporation into the culture medium, it was hypothesized that the BoMx1 pathway possibly was involved, its antiviral spectrum thus probably extending to Paramyxoviridae. In this study, probing of BoMx1-inhibiting effects was carried out by infecting a transgenic Vero cell line that allows tightly regulated conditional expression of BoMx1 after doxycycline treatment with a wide array of Paramyxoviridae. Expressing and nonexpressing cells displayed similar viability, cytopathic effects (CPEs), and amounts of infectious virus yields, whatever the infecting virus or the multiplicity of infection (moi) imposed. It is, therefore, concluded that BoMx1 does not interfere with Paramyxoviridae.
Researchers ; Professionals
http://hdl.handle.net/2268/35021

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