Resistance of paramyxoviridae to type I interferon-induced Bos taurus Mx1 dynamin

[en] Typical targets of type I interferon (IFN)-induced antiviral Mx proteins known to date have been shown to share a common profile: single-stranded negative-sense RNA viruses. Among them, human MxA is known to interfere with the replication of measles, human, and bovine parainfluenza-3 viruses (BoPi3V), that is, three members of the Paramyxoviridae family. Recently, bovine Mx1 protein (BoMx1) was included in the group of Mx proteins with authenticated antiviral potential, as it dramatically represses the replication of vesicular stomatitis virus (VSV). As replication in bovine cells of Pi3, respiratory syncytial (RS), and Sendai (Se) viruses, all members of the same family, is known to be reduced on IFN-alpha incorporation into the culture medium, it was hypothesized that the BoMx1 pathway possibly was involved, its antiviral spectrum thus probably extending to Paramyxoviridae. In this study, probing of BoMx1-inhibiting effects was carried out by infecting a transgenic Vero cell line that allows tightly regulated conditional expression of BoMx1 after doxycycline treatment with a wide array of Paramyxoviridae. Expressing and nonexpressing cells displayed similar viability, cytopathic effects (CPEs), and amounts of infectious virus yields, whatever the infecting virus or the multiplicity of infection (moi) imposed. It is, therefore, concluded that BoMx1 does not interfere with Paramyxoviridae.

Disciplines :

Immunology & infectious disease
Biochemistry, biophysics & molecular biology

Author, co-author :

Leroy, Michael; Université de Liège - ULiège > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies

Baise, Etienne ; Université de Liège - ULiège > Département des sciences de la vie > Macromolécules biologiques

Pire, Grégory; Université de Liège - ULiège > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies

Gérardin, Joël ; Université de Liège - ULiège > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies

Desmecht, Daniel ; Université de Liège - ULiège > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies

Language :

English

Title :

Resistance of paramyxoviridae to type I interferon-induced Bos taurus Mx1 dynamin

Publication date :

2005

Journal title :

Journal of Interferon and Cytokine Research

ISSN :

1079-9907

eISSN :

1557-7465

Publisher :

Mary Ann Liebert Inc, New Rochelle, United States - New York

Volume :

Issue :

Pages :

192-201

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 08 January 2010

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