Reference : Sendai virus-induced alterations in lung structure/function correlate with viral load...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/35020
Sendai virus-induced alterations in lung structure/function correlate with viral loads and reveal a wide resistance/susceptibility spectrum among mouse strains
English
Faisca, Pedro [Université de Liège - ULG > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies > >]
Bui Tran Anh, Dao [Université de Liège - ULG > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies > >]
Desmecht, Daniel mailto [Université de Liège - ULg > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies > >]
2005
American Journal of Physiology - Lung Cellular and Molecular Physiology
American Physiological Society
289
777-787
Yes (verified by ORBi)
International
1040-0605
1522-1504
Bethesda
MD
[en] Sendai virus ; mouse strains ; plethysmography
[en] The Paramyxoviridae family includes some of the most important and ubiquitous disease-causing viruses of infants and children, most of which cause significant infections of the respiratory tract. Evidence is accumulating in humans that genetic factors are involved in the severity of clinical presentation. As a first step toward the identification of the genes involved, this study was undertaken to establish whether laboratory mouse strains differ in susceptibility to Sendai virus, the murine counterpart of human type-1 parainfluenza virus which, historically, has been used extensively in studies that have defined the basic biological properties of paramyxoviruses in general. With this purpose in mind, double-chamber plethysmography data were collected daily for 7 days after inoculation of Sendai virus in six inbred strains of mice. In parallel, histological examinations and lung viral titration were carried out from day 5 to day 7 after inoculation. Pulmonary structure/function values closely reflected the success of viral replication in the lungs and revealed a pattern of continuous variation with resistant, intermediate, and susceptible strains. The results unambiguously suggest that BALB/c (resistant) and 129Sv (susceptible) strains should be used in crossing experiments aimed at identifying the genes involved in resistance to Paramyxoviridae by the positional cloning approach.
Researchers ; Professionals
http://hdl.handle.net/2268/35020

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