Reference : The callipyge mutation enhances bidirectional long-range DLK1-GTL2 intergenic transcr...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/34895
The callipyge mutation enhances bidirectional long-range DLK1-GTL2 intergenic transcription in cis
English
Takeda, Haruko mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Caiment, Florian [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Smit, Maria [Utah State University > College of Agriculture > Animal, Dairy and Veterinary Sciences > >]
Hiard, Samuel mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation > > >]
Tordoir, Xavier mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Cockett, Noelle [Utah State University > College of Agriculture > Animal, Dairy and Veterinary Sciences > >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Charlier, Carole mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
23-May-2006
Proceedings of the National Academy of Sciences USA
103
21
8119-8124
Yes (verified by ORBi)
International
0027-8424
[en] bioinformatics ; callipyge ; mutation ; DLK1-GTL2 ; transcription ; cis
[en] The callipyge mutation (CLPG) is an A to G transition that affects a muscle-specific long-range control element located in the middle of the 90-kb DLK1-GTL2 intergenic (IG) region. It causes ectopic expression of a 327-kb cluster of imprinted genes in skeletal muscle, resulting in the callipyge muscular hypertrophy and its non-Mendelian inheritance pattern known as polar overdominance. We herein demonstrate that the CLPG mutation alters the muscular epigenotype of the DLK1-GTL2 IG region in cis, including hypomethylation, acquisition of novel DNase-I hypersentivite sites, and, most strikingly, strongly enhanced bidirectional, long-range IG transcription. The callipyge phenotype thus emerges as a unique model to study the functional significance of IG transcription, which recently has proven to be a widespread, yet elusive, feature of the mammalian genome.
Systmod
Researchers ; Professionals
http://hdl.handle.net/2268/34895
10.1073/pnas.0602844103
http://www.montefiore.ulg.ac.be/services/stochastic/pubs/2006/TCSHTCGC06

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