Reference : Multifunctional role of matrix metalloproteinases in multiple myeloma: a study in the...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/34892
Multifunctional role of matrix metalloproteinases in multiple myeloma: a study in the 5T2MM mouse model
English
Van Valckenborgh, Els [> >]
Croucher, Peter I. [> >]
De Raeve, Hendrik [> >]
Carron, Chris [> >]
De Leenheer, Evy [> >]
Blacher, Silvia mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Devy, Laetitia [> >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
De Bruyne, Elke [> >]
Asosingh, Kewal [> >]
Van Riet, Ivan [> >]
Van Camp, Ben [> >]
Vanderkerken, Karin [> >]
2004
American Journal of Pathology
American Society for Investigative Pathology
165
3
869-878
Yes (verified by ORBi)
International
0002-9440
1525-2191
Bethesda
MD
[en] Matrix metalloproteinases (MMPs) are known to play a role in cell growth, invasion, angiogenesis, metastasis, and bone degradation, all important events in the pathogenesis of cancer. Multiple myeloma is a B-cell cancer characterized by the proliferation of malignant plasma cells in the bone marrow, increased angiogenesis, and the development of osteolytic bone disease. The role of MMPs in the development of multiple myeloma is poorly understood. Using SC-964, a potent inhibitor of several MMPs (MMP-2, -3, -8, -9, and -13), we investigated the role of MMPs in the 5T2MM murine model. Reverse transcriptase-polymerase chain reaction demonstrated the presence of mRNA for MMP-2, -8, -9, and -13 in 5T2MM-diseased bone marrow. Mice bearing 5T2MM cells were given access to food containing SC-964. The concentration of SC-964 measured in the plasma of mice after 11 days of treatment was able to inhibit MMP-9 activity in gelatin zymography. Treatment of 5T2MM-bearing mice resulted in a significant reduction in tumor burden, a significant decrease in angiogenesis, and partially protective effect against the development of osteolytic bone disease. The direct role of MMPs in these different processes was confirmed by in vitro experiments. All these results support the multifunctional role of MMPs in the development of multiple myeloma.
http://hdl.handle.net/2268/34892

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