Reference : Increased frequency of bronchial hyperresponsiveness in patients with inflammatory bowel...
Scientific journals : Article
Human health sciences : Gastroenterology & hepatology
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/34852
Increased frequency of bronchial hyperresponsiveness in patients with inflammatory bowel disease.
English
Louis, Edouard [Université de Liège - ULg > Département des sciences cliniques > Hépato-gastroentérologie - Relations académiques et scientifiques (Médecine) >]
Louis, Renaud mailto [Université de Liège - ULg > Département des sciences cliniques > Pneumologie - Allergologie]
Drion, V. [> > > >]
Bonnet, V. [> > > >]
Lamproye, Anne [Centre Hospitalier Universitaire de Liège - CHU > > Gastro-Entérologie-Hépatologie >]
Radermecker, Maurice [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
Belaiche, Jacques [Centre Hospitalier Universitaire de Liège - CHU > > Gastro-Entérologie-Hépatologie >]
1995
Allergy
Blackwell
50
9
729-33
Yes (verified by ORBi)
International
0105-4538
1398-9995
Oxford
United Kingdom
[en] Adolescent ; Adult ; Bronchial Hyperreactivity/complications ; Bronchial Provocation Tests ; Female ; Forced Expiratory Volume ; Humans ; Hypersensitivity, Immediate/complications/diagnosis ; Inflammatory Bowel Diseases/complications ; Male ; Methacholine Chloride/diagnostic use ; Middle Aged ; Skin Tests
[en] Although bronchopulmonary manifestations are rare in inflammatory bowel disease (IBD), subclinical abnormalities have been described in up to 50% of cases. The pathophysiology of these abnormalities remains unknown. However, a latent inflammation of the bronchial mucosa secondary to the inflammation of the intestinal mucosa has been suggested. This subclinical inflammation may lead to increased bronchial responsiveness. We studied the bronchial responsiveness in 38 inflammatory bowel disease (IBD) patients, using the methacholine test. Bronchial hyperresponsiveness was defined by a PC20M < 16 mg/ml. Twenty-four healthy controls were also studied. There was no significant difference in baseline FEV1 between IBD patients and controls. However, there was a significantly greater fall in FEV1 in the IBD patients at the concentrations of methacholine tested. The frequency of bronchial hyperresponsiveness was significantly higher in the IBD population (45%) than in controls (17%; P < 0.03). Atopy, defined by skin test, was more common in IBD patients (42%) than in controls (21%). Even when only nonatopic subjects were considered, the frequency of bronchial hyperresponsiveness was significantly higher in IBD patients (41%) than in controls (5%; P < 0.02). Thus, subclinical bronchial hyperresponsiveness is common in IBD, and may be considered a further extraintestinal manifestation.
http://hdl.handle.net/2268/34852
also: http://hdl.handle.net/2268/2291
http://www3.interscience.wiley.com/journal/119243190/issue

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