|Reference : The value of serum CK-MB and myoglobin measurements for assessing perioperative myocardi...|
|Scientific journals : Article|
|Human health sciences : Laboratory medicine & medical technology|
|The value of serum CK-MB and myoglobin measurements for assessing perioperative myocardial infarction after cardiac surgery.|
|Chapelle, Jean-Paul [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]|
|el Allaf, M. [> > > >]|
|Larbuisson, Robert [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]|
|Limet, Raymond [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]|
|Lamy, Maurice [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]|
|Heusghem, C. [> > > >]|
|Scandinavian Journal of Clinical & Laboratory Investigation|
|Taylor & Francis Health Sciences|
|[en] Adult ; Aged ; Chromatography ; Coronary Artery Bypass ; Creatine Kinase/blood ; Electrophoresis ; Female ; Humans ; Immunoenzyme Techniques ; Isoenzymes ; Male ; Middle Aged ; Myocardial Infarction/diagnosis/enzymology/metabolism ; Myoglobin/blood ; Radioimmunoassay|
|[en] In 41 patients who underwent coronary bypass surgery, creatine kinase (CK)-MB mass concentration was repeatedly measured in serum during and after the intervention using a new two-site immunoenzymetric assay (IEMA). Serum CK-MB activity was determined with the use of four different techniques: immunoinhibition, immunoinhibition-immunoprecipitation, column chromatography and electrophoresis. Myoglobin (Mb) was also measured in each specimen by radioimmunoassay. In the 33 patients who followed a completely uneventful postoperative course, the cumulated CK-MB release was, on the average, 12.2-fold less than after acute myocardial infarction. The CK-MB peak concentrations using the IEMA were 33 +/- 3 micrograms/l (X +/- SEM) and occurred 6.4 +/- 0.5 h after the intervention was started; CK-MB levels had decreased to 2.9 +/- 0.4 micrograms/l at the end of the first postoperative day. The evolution of the CK-MB concentration was parallel to that of the enzyme activity. The serum Mb maximum concentrations (518 +/- 39 micrograms/l) were reached after 3.3 +/- 0.1 h. The other eight patients developed perioperative myocardial infarction (PMI); in this group, the cumulated CK-MB release was higher, and the serum CK-MB postoperative curves were of three different types. The patients with delayed CK-MB peaks (type I pattern) or sustained elevations (type III) of this isoenzyme also showed increased serum Mb levels at the end of the first postoperative day. The PMI patients with early (10 h) CK-MB elevations (type II) did not demonstrate abnormal serum Mb levels.(ABSTRACT TRUNCATED AT 250 WORDS)|
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