|Reference : Serum creatine kinase isoenzyme MB concentration after endomyocardial biopsy.|
|Scientific journals : Article|
|Human health sciences : Laboratory medicine & medical technology|
|Serum creatine kinase isoenzyme MB concentration after endomyocardial biopsy.|
|Chapelle, Jean-Paul [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]|
|El Allaf, Dia [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]|
|el Allaf, M. [> > > >]|
|Heusghem, C. [> > > >]|
|Carlier, J. [> > > >]|
|Kulbertus, Henri [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]|
|Clinica Chimica Acta|
|[en] Adult ; Aged ; Biopsy/adverse effects ; Cardiomyopathies/enzymology/etiology/pathology ; Creatine Kinase/blood ; Female ; Humans ; Isoenzymes ; Kinetics ; Male ; Middle Aged ; Myocardium/enzymology/pathology|
|[en] Serum total creatine kinase (CK), CK-MB and myoglobin (Mb) were serially determined in 17 patients who underwent endomyocardial biopsy. Mean total CK levels increased from 36 +/- 27 U/l 30 min before biopsy to a maximum of 112 +/- 77 U/l 8 h following the procedure (p less than 0.05). Similarly, Mb concentrations rose from 57 +/- 55 micrograms/l to 119 +/- 57 micrograms/l 30 min after biopsy (p less than 0.05). Normalization of total CK and Mb levels occurred within 16 and 8 h, respectively. A new immunoenzymetric assay (IEMA) was used to measure the mass concentration of the CK-MB molecule. The initial CK-MB levels were 0.2 +/- 0.4 microgram/l; a small but significant elevation was recorded as early as 2 h after biopsy (1.6 +/- 1.5 micrograms/l, p less than 0.05). CK-MB returned to initial concentration 16 h after the beginning of the procedure. Comparison with the maximum CK-MB levels recorded in 16 myocardial infarction patients (258 +/- 172 micrograms/l, range 90-680 micrograms/l) indicated that the modest increase of CK-MB level detected after biopsy probably reflects a limited endomyocardium lesion at the sampling site, excluding any significant myocardial damage. Total CK and Mb, which showed more pronounced elevations than CK-MB, are likely to originate from other sources than the myocardium.|
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