Article (Scientific journals)
On the interpretation of serial laboratory measurements in acute myocardial infarction.
Albert, Adelin; Harris, E. K.; CHAPELLE, Jean-Paul et al.
1984In Clinical Chemistry, 30 (1), p. 69-76
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Keywords :
Acute Disease; Age Factors; Aged; Blood Urea Nitrogen; Female; Humans; L-Lactate Dehydrogenase/blood; Male; Middle Aged; Myocardial Infarction/blood/mortality; Orosomucoid/blood; Prognosis; Risk; Time Factors
Abstract :
[en] Serial laboratory determinations are now routinely performed on patients admitted to intensive-care units. Adequate interpretation of such cumulative information for clinical decision-making purposes is a challenging problem. We describe a statistical method for predicting--sequentially as the data become available--the patient's outcome, death or survival. Thus, the method goes beyond previously reported techniques that base such prediction on only a single multivariate observation. The method has been applied to daily measurements of serum urea and lactate dehydrogenase, performed during one week on patients hospitalized in the coronary-care unit with acute myocardial infarction. Two baseline variables were also included in the dynamic risk index so derived: the age of the patient and the number of previous myocardial infarctions recorded on admission. We also discuss the problems of selecting the most-predictive laboratory tests and of determining for each test the amount of past data needed to achieve satisfactory prediction. We distinguish between global evaluation of the dynamic risk index obtained (in terms of specificity and sensitivity) and individual interpretation (in terms of posterior/prior probability ratio) of a given risk score for a particular patient. The approach described may contribute to more effective use of results of repeated laboratory tests on critically ill patients.
Disciplines :
Laboratory medicine & medical technology
General & internal medicine
Author, co-author :
Albert, Adelin  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
Harris, E. K.
CHAPELLE, Jean-Paul ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Heusghem, Camille
Kulbertus, Henri ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
On the interpretation of serial laboratory measurements in acute myocardial infarction.
Publication date :
January 1984
Journal title :
Clinical Chemistry
ISSN :
0009-9147
eISSN :
1530-8561
Publisher :
American Association for Clinical Chemistry, Washington, United States - District of Columbia
Volume :
30
Issue :
1
Pages :
69-76
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 February 2010

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