Reference : The callipyge (CLPG) mutation enhances the expression of the coregulated DLK1, GTL2, PEG...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/34424
The callipyge (CLPG) mutation enhances the expression of the coregulated DLK1, GTL2, PEG11 and MEG8 genes in cis without affecting their imprinting status
English
Charlier, Carole mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Segers, K. [> >]
Karim, Latifa mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Shay, T. [> >]
Gyapay, G. [> >]
Cockett, N. [> >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
2001
Nature Genetics
Nature Publishing Group
27
367-369
Yes (verified by ORBi)
International
1061-4036
1546-1718
New York
NY
[en] The callipyge (CLPG) phenotype (from kappa(alpha)lambda(iota), "beautiful," and pi(iota)gamma(epsilon), "buttocks") described in sheep is an inherited muscular hypertrophy that is subject to an unusual parent-of-origin effect referred to as polar overdominance: only heterozygous individuals having inherited the CLPG mutation from their sire exhibit the muscular hypertrophy. The callipyge (clpg) locus was mapped to a chromosome segment of approximately 400 kb (refs. 2-4), which was shown to contain four genes (DLK1, GTL2, PEG11 and MEG8) that are preferentially expressed in skeletal muscle and subject to parental imprinting in this tissue. Here we describe the effect of the CLPG mutation on the expression of these four genes, and demonstrate that callipyge individuals have a unique expression profile that may account for the observed polar overdominance.
Researchers ; Professionals
http://hdl.handle.net/2268/34424

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