Article (Scientific journals)
A Rank-Based Nonparametric Method for Mapping Quantitative Trait Loci in Outbred Half-Sib Pedigrees: Application to Milk Production in a Granddaughter Design
Coppieters, Wouter; Kvasz, A.; Farnir, Frédéric et al.
1998In Genetics, 149 (3), p. 1547-55
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Abstract :
[en] We describe the development of a multipoint nonparametric quantitative trait loci mapping method based on the Wilcoxon rank-sum test applicable to outbred half-sib pedigrees. The method has been evaluated on a simulated dataset and its efficiency compared with interval mapping by using regression. It was shown that the rank-based approach is slightly inferior to regression when the residual variance is homoscedastic normal; however, in three out of four other scenarios envisaged, i.e., residual variance heteroscedastic normal, homoscedastic skewed, and homoscedastic positively kurtosed, the latter outperforms the former one. Both methods were applied to a real data set analyzing the effect of bovine chromosome 6 on milk yield and composition by using a 125-cM map comprising 15 microsatellites and a granddaughter design counting 1158 Holstein-Friesian sires.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Coppieters, Wouter ;  Université de Liège - ULiège > Département de productions animales > Département de productions animales
Kvasz, A.
Farnir, Frédéric  ;  Université de Liège - ULiège > Département de productions animales > Biostatistique, économie, sélection animale
Arranz, J. J.
Grisart, B.
Mackinnon, M.
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > Génomique animale
Language :
English
Title :
A Rank-Based Nonparametric Method for Mapping Quantitative Trait Loci in Outbred Half-Sib Pedigrees: Application to Milk Production in a Granddaughter Design
Publication date :
1998
Journal title :
Genetics
ISSN :
0016-6731
eISSN :
1943-2631
Publisher :
Genetics Society of America, United States - Maryland
Volume :
149
Issue :
3
Pages :
1547-55
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 January 2010

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