|Reference : The Ovine Callipyge Locus: A Paradigm Illustrating the Importance of Non-Mendelian Genet...|
|Scientific journals : Article|
|Life sciences : Veterinary medicine & animal health|
|The Ovine Callipyge Locus: A Paradigm Illustrating the Importance of Non-Mendelian Genetics in Livestock|
|Georges, Michel [Université de Liège - ULg > Département de productions animales > Génomique animale >]|
|Cockett, N. [> > > >]|
|Reproduction Nutrition Development|
|[en] An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge (CLPG) gene mapped to ovine chromosome 18. We demonstrate in this work that the callipyge phenotype is characterized by a non-Mendelian inheritance pattern, referred to as polar overdominance, in which only heterozygous individuals having inherited the CLPG mutation from their sire express the phenotype. The possible role of parental imprinting in the determinism of polar overdominance is envisaged.|
|Researchers ; Professionals|
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