Reference : Molecular Definition of an Allelic Series of Mutations Disrupting the Myostatin Function...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/34391
Molecular Definition of an Allelic Series of Mutations Disrupting the Myostatin Function and Causing Double-Muscling in Cattle
English
Grobet, Luc mailto [Université de Liège - ULg > Département de morphologie et pathologie > Embryologie >]
Poncelet, D. [> >]
Royo, L. J. [> > > >]
Brouwers, B. [> >]
Pirottin, Dimitri mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Geudvert, C. [> >]
Menissier, F. [> > > >]
Zanotti, M. [> > > >]
Dunner, S. [> > > >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
1998
Mammalian Genome : Official Journal of the International Mammalian Genome Society
9
3
210-3
Yes
International
0938-8990
[en] We have determined the entire myostatin coding sequence for 32 double-muscled cattle sampled from ten European cattle breeds. Seven DNA sequence polymorphisms were identified, of which five would be predicted to disrupt the function of the protein, one is a conservative amino acid substitution, and one a silent DNA sequence variant. Four additional DNA sequence polymorphisms were identified in myostatin intronic sequences. In all but two breeds, all double-muscled animals were either homozygous or compound heterozygotes for one of the five loss-of-function mutations. The absence of obvious loss-of-function mutations in the coding sequence of the two remaining breeds points either towards additional mutations in unexplored segments of the gene, or towards locus heterogeneity of double-muscling.
Researchers ; Professionals
http://hdl.handle.net/2268/34391
10.1007/s003359900727

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
GrobetL-MammGen-1998.pdfPublisher postprint1.22 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.