Reference : IBD mapping of recessive traits in livestock: application to map the bovine syndactyl...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/34390
IBD mapping of recessive traits in livestock: application to map the bovine syndactyly locus to chromosome 15
English
Charlier, Carole mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Farnir, Frédéric mailto [Université de Liège - ULg > Département de productions animales > Biostatistique, économie, sélection animale >]
Berzi, P. [> >]
Vanmanshoven, P. [> >]
Brouwers, B. [> >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
1996
Genome Research
Cold Spring Harbor Laboratory Press
6
580-589
Yes (verified by ORBi)
International
1088-9051
Cold Spring Harbor
NY
[en] Twelve animals affected with syndactyly or mulefoot were sampled in the Dutch black-and-white cattle population. Analysis of the pedigree data reveal that all of these individuals traced back to a single acknowledged carrier founder individual. Between seven and nine generations separated the founder from its 12 affected descendents. The 12 affected offspring were genotyped for a battery of 213 microsatellites spanning the 29 bovine autosomes. The resulting genotypes were analyzed using a maximum likelihood approach searching for shared homozygous haplotypes among affected individuals. Three candidate regions for the syndactyly locus emerged from this initial screening. syndactyly was shown to map to one of these candidate regions on chromosome 15 by genotyping 29 additional individuals linking founder and affected offspring and performing a conventional linkage analysis with the LINKAGE programs. This study illustrates the potential of identity-by-descent mapping in livestock populations.
Researchers ; Professionals
http://hdl.handle.net/2268/34390
10.1101/gr.6.7.580

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